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- W2883326549 abstract "Activity-dependent myelination modulates neuron conduction velocity and as such it is essential for a correct wiring of a whole nervous system. Increasing myelination through inducing neuron activity has been proposed as a treatment strategy for demyelination diseases. Yet, the mechanisms and the effects of activity-dependent myelination remain elusive—new tools are needed. In this chapter, we describe a novel compartmentalized device integrated with an optogenetic stimulator for studying activity-dependent myelination in vitro. The platform can be modified to include multiple cell types, stimulation modes, and experimental readouts to answer a specific research question. This versatility combined with a precise control over spatial extent of the stimulation and the stimulation pattern make the proposed platform a valuable tool for molecular myelination studies." @default.
- W2883326549 created "2018-08-03" @default.
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- W2883326549 date "2018-01-01" @default.
- W2883326549 modified "2023-10-18" @default.
- W2883326549 title "Subcellular Optogenetic Stimulation Platform for Studying Activity-Dependent Axon Myelination In Vitro" @default.
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- W2883326549 doi "https://doi.org/10.1007/978-1-4939-7862-5_16" @default.
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