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- W2883338700 abstract "Objective. To explore the association between the acquisition process in the Y-maze and H-2 class II polymorphisms in mice. Methods. Mice were trained for 5 consecutive days in the Y-maze. The value of the slope of the latent period was considered an indication for the acquisition process. A slope < 0 indicated learning during the training and a slope > 0 indicated no learning. The H-2 polymorphism was determined with PCR amplification, and the correlation between the alleles and the acquisition process was analyzed. Results. The overall percentage of mice that learned was 46.1%. The percentage of mice that had learned with MudoEb5 (37.9%) was significantly lower than that of mice without MudoEb5 (61.1%; P < 0.05). The percentage of mice that had learned with MudoEb7 (26.1%) was significantly lower than that of mice without MudoEb7 (51.9%; P < 0.05). Conclusions. The major histocompatibility complex (MHC) and other alleles may be involved in the acquisition process. There may be a biological basis for learning in mice." @default.
- W2883338700 created "2018-08-03" @default.
- W2883338700 creator A5071478076 @default.
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- W2883338700 date "2018-07-19" @default.
- W2883338700 modified "2023-10-16" @default.
- W2883338700 title "Association between Y-Maze Acquisition Learning and Major Histocompatibility Complex Class II Polymorphisms in Mice" @default.
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- W2883338700 doi "https://doi.org/10.1155/2018/6381932" @default.
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