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- W2883380562 abstract "Abstract Dynamic evolutionary processes and complex structure make the Y chromosome among the most diverse and least understood regions in mammalian genomes. Here, we present an annotated assembly of the male specific region of the horse Y chromosome (eMSY), representing the first comprehensive Y assembly in odd-toed ungulates. The eMSY comprises single-copy, equine specific multi-copy, PAR transposed, and novel ampliconic sequence classes. The eMSY gene density approaches that of autosomes with the highest number of retained X–Y gametologs recorded in eutherians, in addition to novel Y-born and transposed genes. Horse, donkey and mule testis RNAseq reveals several candidate genes for stallion fertility. A novel testis-expressed XY ampliconic sequence class, ETSTY7 , is shared with the parasite Parascaris genome, providing evidence for eukaryotic horizontal transfer and inter-chromosomal mobility. Our study highlights the dynamic nature of the Y and provides a reference sequence for improved understanding of equine male development and fertility." @default.
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- W2883380562 date "2018-07-27" @default.
- W2883380562 modified "2023-10-03" @default.
- W2883380562 title "Horse Y chromosome assembly displays unique evolutionary features and putative stallion fertility genes" @default.
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- W2883380562 doi "https://doi.org/10.1038/s41467-018-05290-6" @default.
- W2883380562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6063916" @default.
- W2883380562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30054462" @default.
- W2883380562 hasPublicationYear "2018" @default.
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