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- W2883403291 endingPage "2589" @default.
- W2883403291 startingPage "2579" @default.
- W2883403291 abstract "R loops are transient three-stranded nucleic acid structures that form physiologically during transcription when a nascent RNA transcript hybridizes with the DNA template strand, leaving a single strand of displaced nontemplate DNA. However, aberrant persistence of R-loops can cause DNA damage by inducing genomic instability. Indeed, evidence has emerged that R-loops might represent a key element in the pathogenesis of human diseases, including cancer, neurodegeneration, and motor neuron disorders. Mutations in genes directly involved in R-loop biology, such as SETX (senataxin), or unstable DNA expansion eliciting R-loop generation, such as C9ORF72 HRE, can cause DNA damage and ultimately result in motor neuron cell death. In this review, we discuss current advancements in this field with a specific focus on motor neuron diseases associated with deregulation of R-loop structures. These mechanisms can represent novel therapeutic targets for these devastating, incurable diseases." @default.
- W2883403291 created "2018-08-03" @default.
- W2883403291 creator A5020986127 @default.
- W2883403291 creator A5038271133 @default.
- W2883403291 creator A5055985759 @default.
- W2883403291 creator A5060263136 @default.
- W2883403291 creator A5076321492 @default.
- W2883403291 date "2018-07-25" @default.
- W2883403291 modified "2023-10-18" @default.
- W2883403291 title "R-Loops in Motor Neuron Diseases" @default.
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