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- W2883408968 abstract "A simple and convenient protocol has been developed for the synthesis of N-amino-3-cyano-2-pyridone derivatives by a one-pot reaction of cyanoacetohydrazide, activated nitrile substrates (malononitrile, ethyl cyanoacetate, cyanoacetamide) and aromatic aldehydes in the presence of piperidine in water or a mixture of water and ethanol. The sequence of cascade reactions includes Knoevenagel condensation, Michael addition, intramolecular cyclization, imine-enamine tautomerization and oxidative aromatization. The main advantages of this procedure are availability of starting compounds, simple procedure, mild conditions, easy purification of products and the use of water or water/ethanol as green solvents." @default.
- W2883408968 created "2018-08-03" @default.
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- W2883408968 date "2018-01-01" @default.
- W2883408968 modified "2023-10-14" @default.
- W2883408968 title "An efficient and ecofriendly synthesis of highly functionalized pyridones <i>via</i> a one-pot three-component reaction" @default.
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- W2883408968 doi "https://doi.org/10.1039/c8ra05690k" @default.
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