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• W2883427337 abstract "Checkpoint immunotherapy uses highly selective humanized monoclonal antibodies against checkpoint signals such as programmed cell death receptor (PD-1) and programmed cell death ligand (PD-L1). By blocking these receptors and signals, the immune system can be reactivated to fight the tumor. Immunotherapy for advanced non-small cell lung cancer (NSCLC) has resulted in a new paradigm of treatment options resulting in improved survival and response rates and has a less severe yet unique toxicity profile when compared to chemotherapy. PD-1 inhibitors, nivolumab and pembrolizumab, and PD-L1 inhibitor, atezolizumab, are currently approved by regulatory authorities for the treatment of advanced NSCLC. This article provides a detailed review of these newer agents, their mechanism of action, side-effect profile, therapeutic indications and current evidence supporting their use in the management of NSCLC." @default.
• W2883427337 created "2018-08-03" @default.
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• W2883427337 date "2018-07-01" @default.
• W2883427337 modified "2023-10-13" @default.
• W2883427337 title "Review of checkpoint immunotherapy for the management of non-small cell lung cancer" @default.
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• W2883427337 doi "https://doi.org/10.2147/itt.s125070" @default.
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