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• W2883446539 abstract "Summary Context Although metabolic syndrome has been studied in patients with autonomous cortisol secretion, there are limited data for those with nonfunctioning adrenal incidentaloma ( NFAI ). Objective To assess metabolic syndrome frequency in NFAI patients and controls without adrenal adenoma according to World Health Organization ( WHO ), National Cholesterol Education Program‐Adult Treatment Panel III ( NCEP ‐ ATP III ), American Association of Clinical Endocrinologists/American College of Endocrinology ( AACE / ACE ) and International Diabetes Federation ( IDF ) criteria. Design Retrospective and transversal study. Patients Seventy‐four NFAI and 90 controls were evaluated. NFAI diagnosis was established according to current guidelines. The control group was selected based on normal adrenal imaging examinations. Measurements Subjects were categorized by metabolic syndrome presence according to WHO , NCEP ‐ ATP III , AACE / ACE and IDF . Results Age, gender, ethnicity, body mass index, smoking, menopause, statin and fibrate use were comparable between patients and controls. The frequency of prediabetes, dyslipidaemia and hypertension as well as waist circumference were significantly higher in the NFAI patients compared to the controls. The metabolic syndrome frequency in the NFAI group was significantly higher compared to the normal adrenal group: WHO : 69.2% × 31.0% ( P < 0.001); NCEP ‐ ATP III : 81.7% × 44.9% ( P < 0.001); AACE / ACE : 77.1% × 31.9% ( P < 0.001); IDF : 78.6% × 45.5% ( P < 0.001). Logistic regression analysis showed that NFAI was a predictor of metabolic syndrome according to WHO ( P = 0.001), NCEP ‐ ATP III ( P = 0.005) and AACE / ACE ( P = 0.007). Conclusions Metabolic syndrome is frequently found in patients with NFAI , and this frequency is higher in NFAI patients than in those with normal adrenal imaging." @default.
• W2883446539 created "2018-08-03" @default.
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• W2883446539 date "2018-08-21" @default.
• W2883446539 modified "2023-09-30" @default.
• W2883446539 title "Nonfunctioning adrenal incidentaloma: A novel predictive factor for metabolic syndrome" @default.
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• W2883446539 doi "https://doi.org/10.1111/cen.13822" @default.
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