FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883460206> ?p ?o ?g. }

• W2883460206 endingPage "30526" @default.
• W2883460206 startingPage "30513" @default.
• W2883460206 abstract "Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3B (APOBEC3B) is a gene editing enzyme with cytidine deaminase activity and high expression of its mRNA in breast tumors have been shown to be associated with progressive cases and poor prognosis. In this study, we aimed to examine the relationship between the expression of APOBEC3B and the effect of neoadjuvant chemotherapy (NAC) using pretreatment biopsy tissue, and examined whether the expression of APOBEC3B influenced chemotherapy efficacy.We retrospectively selected a total of 274 patients with primary breast cancer who received NAC in more than 4 courses and underwent surgery at our institute. We assessed the expression of APOBEC3B mRNA using pretreatment biopsy specimens of NAC by quantitative real-time PCR (qRT-PCR) and examined the relationship between APOBEC3B mRNA expression and sensitivity to chemotherapy using pathological complete response (pCR) as an indicator. Further, we assessed the prognostic value of APOBEC3B in the patients receiving NAC.APOBEC3B mRNA expression levels were successfully assessed in 173 (63.1%) of the 274 specimens. The total pCR rate was 36.4% (n = 63). An association between APOBEC3B expression levels and pCR was observed (Wilcoxon test, P ≤ 0.0001). The patients were divided into two groups, low (n = 66) and high (n = 107), according to the APOBEC3B expression levels, using the cut-off value calculated by the receiver operating characteristics (ROC) curve for pCR. The rate of pCR was significantly higher among the patients in the high group than among those in the low group (47.7% vs 18.2%, P ≤ 0.0001). High APOBEC3B expression was significantly associated with high nuclear grade (P = 0.0078), high Ki-67 labeling index (P = 0.0087), estrogen receptor (ER) negativity (P ≤ 0.0001) and human epidermal growth factor receptor 2 (HER2) negativity (P = 0.032). Tumor size (P = 0.011), ER (P ≤ 0.0001), HER2 (P = 0.0013) and APOBEC3B expression (P = 0.037) were independent predictive factors for pCR in multivariate analysis. However, there was no association between APOBEC3B expression and prognosis.Our study showed that APOBEC3B mRNA expression correlated with sensitivity to NAC in breast cancer patients. In contrast to previous studies, APOBEC3B mRNA expression was not associated with breast cancer prognosis in patients receiving NAC." @default.
• W2883460206 created "2018-08-03" @default.
• W2883460206 creator A5018788633 @default.
• W2883460206 creator A5024725726 @default.
• W2883460206 creator A5035071748 @default.
• W2883460206 creator A5041066302 @default.
• W2883460206 creator A5044478653 @default.
• W2883460206 creator A5059659575 @default.
• W2883460206 creator A5087154078 @default.
• W2883460206 creator A5087891477 @default.
• W2883460206 date "2018-07-17" @default.
• W2883460206 modified "2023-09-23" @default.
• W2883460206 title "APOBEC3B gene expression as a novel predictive factor for pathological complete response to neoadjuvant chemotherapy in breast cancer" @default.
• W2883460206 cites W1533555842 @default.
• W2883460206 cites W1763675400 @default.
• W2883460206 cites W1792154290 @default.
• W2883460206 cites W1912384544 @default.
• W2883460206 cites W1974685860 @default.
• W2883460206 cites W1978469053 @default.
• W2883460206 cites W1979946545 @default.
• W2883460206 cites W1984236815 @default.
• W2883460206 cites W1990993204 @default.
• W2883460206 cites W1994697487 @default.
• W2883460206 cites W1996486420 @default.
• W2883460206 cites W2003298449 @default.
• W2883460206 cites W2003665515 @default.
• W2883460206 cites W2015960413 @default.
• W2883460206 cites W2023568503 @default.
• W2883460206 cites W2024792080 @default.
• W2883460206 cites W2025883350 @default.
• W2883460206 cites W2030457654 @default.
• W2883460206 cites W2044702943 @default.
• W2883460206 cites W2057623606 @default.
• W2883460206 cites W2061582141 @default.
• W2883460206 cites W2068759791 @default.
• W2883460206 cites W2073618702 @default.
• W2883460206 cites W2075894019 @default.
• W2883460206 cites W2083803850 @default.
• W2883460206 cites W2085177488 @default.
• W2883460206 cites W2087179076 @default.
• W2883460206 cites W2091975775 @default.
• W2883460206 cites W2096283457 @default.
• W2883460206 cites W2101836667 @default.
• W2883460206 cites W2101979288 @default.
• W2883460206 cites W2104153021 @default.
• W2883460206 cites W2105219549 @default.
• W2883460206 cites W2105882193 @default.
• W2883460206 cites W2117692326 @default.
• W2883460206 cites W2128985829 @default.
• W2883460206 cites W2129136620 @default.
• W2883460206 cites W2130741439 @default.
• W2883460206 cites W2131793664 @default.
• W2883460206 cites W2131915049 @default.
• W2883460206 cites W2132619562 @default.
• W2883460206 cites W2132767411 @default.
• W2883460206 cites W2138734774 @default.
• W2883460206 cites W2147415463 @default.
• W2883460206 cites W2150134401 @default.
• W2883460206 cites W2151859419 @default.
• W2883460206 cites W2152061559 @default.
• W2883460206 cites W2153158488 @default.
• W2883460206 cites W2159082261 @default.
• W2883460206 cites W2161109798 @default.
• W2883460206 cites W2164774797 @default.
• W2883460206 cites W2184119346 @default.
• W2883460206 cites W2221435694 @default.
• W2883460206 cites W2278216532 @default.
• W2883460206 cites W2527662309 @default.
• W2883460206 cites W2546628787 @default.
• W2883460206 cites W2560367415 @default.
• W2883460206 cites W2563719592 @default.
• W2883460206 cites W2588219859 @default.
• W2883460206 cites W4233358210 @default.
• W2883460206 cites W4240237951 @default.
• W2883460206 doi "https://doi.org/10.18632/oncotarget.25495" @default.
• W2883460206 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6078135" @default.
• W2883460206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30093965" @default.
• W2883460206 hasPublicationYear "2018" @default.
• W2883460206 type Work @default.
• W2883460206 sameAs 2883460206 @default.
• W2883460206 citedByCount "6" @default.
• W2883460206 countsByYear W28834602062020 @default.
• W2883460206 countsByYear W28834602062021 @default.
• W2883460206 countsByYear W28834602062022 @default.
• W2883460206 countsByYear W28834602062023 @default.
• W2883460206 crossrefType "journal-article" @default.
• W2883460206 hasAuthorship W2883460206A5018788633 @default.
• W2883460206 hasAuthorship W2883460206A5024725726 @default.
• W2883460206 hasAuthorship W2883460206A5035071748 @default.
• W2883460206 hasAuthorship W2883460206A5041066302 @default.
• W2883460206 hasAuthorship W2883460206A5044478653 @default.
• W2883460206 hasAuthorship W2883460206A5059659575 @default.
• W2883460206 hasAuthorship W2883460206A5087154078 @default.
• W2883460206 hasAuthorship W2883460206A5087891477 @default.
• W2883460206 hasBestOaLocation W28834602061 @default.
• W2883460206 hasConcept C104317684 @default.
• W2883460206 hasConcept C121608353 @default.
• W2883460206 hasConcept C126322002 @default.

• next