FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883461429> ?p ?o ?g. }

• W2883461429 endingPage "41" @default.
• W2883461429 startingPage "34" @default.
• W2883461429 abstract "Fowl adenovirus serotype 4 (FAdV-4) is a hepatotrophic virus that causes severe liver diseases. Upon histological examination, the most remarkable findings in the liver are small multifocal areas of necrosis and mononuclear cell infiltration, including basophilic intranuclear inclusion bodies in hepatocytes surrounded by a clear halo or which fill the entire nucleus. Here, we examined the mechanism responsible for FAdV-4-mediated hepatocyte damage in vivo and in vitro. The results showed that FAdV-4 impaired liver integrity and function, which decreased albumin and blood glucose concentrations and increased the plasma activity of aspartate aminotransferase and lactate dehydrogenase, compared with a non-infected control group (P<0.05). FAdV-4 induced hepatocyte apoptosis in a time-dependent manner in vivo and in vitro. Additionally, we found that FAdV-4 also induced the autophagy of hepatocytes, which promoted the conversion of microtubule-associated protein light chain 3 (LC3-I) to LC3-II, which is a hallmarks of autophagy. Furthermore, the mRNA expressions of interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α in vivo and in vitro showed a statistically significant increase (P<0.05) compared to that of the control group. However, the molecular mechanisms underlying the FAdV-4-induced apoptotic and autophagic cell death remain unclear. In summation, our observations suggested that FAdV-4 induced liver injury via apoptosis, autophagy, and a severe inflammatory response." @default.
• W2883461429 created "2018-08-03" @default.
• W2883461429 creator A5002467100 @default.
• W2883461429 creator A5003631389 @default.
• W2883461429 creator A5012724541 @default.
• W2883461429 creator A5020493823 @default.
• W2883461429 creator A5040436559 @default.
• W2883461429 creator A5054688353 @default.
• W2883461429 creator A5083520305 @default.
• W2883461429 date "2018-09-01" @default.
• W2883461429 modified "2023-09-27" @default.
• W2883461429 title "Fowl adenovirus serotype 4-induced apoptosis, autophagy, and a severe inflammatory response in liver" @default.
• W2883461429 cites W1560977824 @default.
• W2883461429 cites W1940061719 @default.
• W2883461429 cites W1990551192 @default.
• W2883461429 cites W1991105254 @default.
• W2883461429 cites W1993678138 @default.
• W2883461429 cites W1996758156 @default.
• W2883461429 cites W2004312418 @default.
• W2883461429 cites W2004620707 @default.
• W2883461429 cites W2021462645 @default.
• W2883461429 cites W2030177843 @default.
• W2883461429 cites W2030798940 @default.
• W2883461429 cites W2031949802 @default.
• W2883461429 cites W2035376519 @default.
• W2883461429 cites W2038246430 @default.
• W2883461429 cites W2042943782 @default.
• W2883461429 cites W2043376907 @default.
• W2883461429 cites W2072316695 @default.
• W2883461429 cites W2077042147 @default.
• W2883461429 cites W2079825767 @default.
• W2883461429 cites W2107466897 @default.
• W2883461429 cites W2124371255 @default.
• W2883461429 cites W2124476064 @default.
• W2883461429 cites W2125985645 @default.
• W2883461429 cites W2126274512 @default.
• W2883461429 cites W2136860699 @default.
• W2883461429 cites W2140198857 @default.
• W2883461429 cites W2142534404 @default.
• W2883461429 cites W2161674613 @default.
• W2883461429 cites W2165922840 @default.
• W2883461429 cites W2168412437 @default.
• W2883461429 cites W2312657685 @default.
• W2883461429 cites W2493698333 @default.
• W2883461429 cites W2760727249 @default.
• W2883461429 doi "https://doi.org/10.1016/j.vetmic.2018.07.014" @default.
• W2883461429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30173749" @default.
• W2883461429 hasPublicationYear "2018" @default.
• W2883461429 type Work @default.
• W2883461429 sameAs 2883461429 @default.
• W2883461429 citedByCount "31" @default.
• W2883461429 countsByYear W28834614292019 @default.
• W2883461429 countsByYear W28834614292020 @default.
• W2883461429 countsByYear W28834614292021 @default.
• W2883461429 countsByYear W28834614292022 @default.
• W2883461429 countsByYear W28834614292023 @default.
• W2883461429 crossrefType "journal-article" @default.
• W2883461429 hasAuthorship W2883461429A5002467100 @default.
• W2883461429 hasAuthorship W2883461429A5003631389 @default.
• W2883461429 hasAuthorship W2883461429A5012724541 @default.
• W2883461429 hasAuthorship W2883461429A5020493823 @default.
• W2883461429 hasAuthorship W2883461429A5040436559 @default.
• W2883461429 hasAuthorship W2883461429A5054688353 @default.
• W2883461429 hasAuthorship W2883461429A5083520305 @default.
• W2883461429 hasConcept C150903083 @default.
• W2883461429 hasConcept C153911025 @default.
• W2883461429 hasConcept C17991360 @default.
• W2883461429 hasConcept C190283241 @default.
• W2883461429 hasConcept C202751555 @default.
• W2883461429 hasConcept C203014093 @default.
• W2883461429 hasConcept C203522944 @default.
• W2883461429 hasConcept C207001950 @default.
• W2883461429 hasConcept C2776200302 @default.
• W2883461429 hasConcept C31573885 @default.
• W2883461429 hasConcept C503630168 @default.
• W2883461429 hasConcept C54355233 @default.
• W2883461429 hasConcept C55493867 @default.
• W2883461429 hasConcept C86803240 @default.
• W2883461429 hasConceptScore W2883461429C150903083 @default.
• W2883461429 hasConceptScore W2883461429C153911025 @default.
• W2883461429 hasConceptScore W2883461429C17991360 @default.
• W2883461429 hasConceptScore W2883461429C190283241 @default.
• W2883461429 hasConceptScore W2883461429C202751555 @default.
• W2883461429 hasConceptScore W2883461429C203014093 @default.
• W2883461429 hasConceptScore W2883461429C203522944 @default.
• W2883461429 hasConceptScore W2883461429C207001950 @default.
• W2883461429 hasConceptScore W2883461429C2776200302 @default.
• W2883461429 hasConceptScore W2883461429C31573885 @default.
• W2883461429 hasConceptScore W2883461429C503630168 @default.
• W2883461429 hasConceptScore W2883461429C54355233 @default.
• W2883461429 hasConceptScore W2883461429C55493867 @default.
• W2883461429 hasConceptScore W2883461429C86803240 @default.
• W2883461429 hasLocation W28834614291 @default.
• W2883461429 hasLocation W28834614292 @default.
• W2883461429 hasOpenAccess W2883461429 @default.
• W2883461429 hasPrimaryLocation W28834614291 @default.
• W2883461429 hasRelatedWork W1504336579 @default.
• W2883461429 hasRelatedWork W1973111465 @default.

• next