Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883485382> ?p ?o ?g. }
- W2883485382 endingPage "72" @default.
- W2883485382 startingPage "65" @default.
- W2883485382 abstract "Ebola virus disease is a deadly infection which occurs in sporadic outbreaks. Several vaccine candidates have been developed. The most advanced candidate is the recombinant VSVΔG-ZEBOV-GP vaccine, in which the Vesicular Stomatitis Virus (VSV) envelope glycoprotein is replaced by the Zaire strain Ebola virus (ZEBOV) glycoprotein (GP). This vaccine demonstrated 100% protection in a ring vaccination trial performed in Guinea in 2015, was granted “Breakthrough Therapy Designation” by the FDA and PRIority Medicines (PRIME), and is currently (June 2018) used to support outbreak control in Democratic Republic of Congo. rVSVΔG-ZEBOV-GP elicits a strong and durable antibody response in most vaccinees. This sustained Ebola GP-specific antibody response correlates with an early activation of innate immunity, especially of monocytes and of type-I interferon induced genes. Despite significant progress in the characterization of vaccine-induced immunity, human correlates of protection against Ebolavirus infection have not yet been fully established. A systems biology approach, integrating clinical, immunological, transcriptomic and metabolomic data from pre-clinical and clinical vaccine studies, together with data from disease survivors, will be instrumental to identify Ebola vaccine correlates of protection. The information generated for the rVSVΔG-ZEBOV-GP vaccine may also help identify the correlates of protection of the other Ebola vaccine candidates." @default.
- W2883485382 created "2018-08-03" @default.
- W2883485382 creator A5010371900 @default.
- W2883485382 creator A5030631117 @default.
- W2883485382 creator A5069089383 @default.
- W2883485382 date "2018-10-01" @default.
- W2883485382 modified "2023-10-16" @default.
- W2883485382 title "Correlates of vaccine-induced protective immunity against Ebola virus disease" @default.
- W2883485382 cites W1614627200 @default.
- W2883485382 cites W1757890151 @default.
- W2883485382 cites W1814034318 @default.
- W2883485382 cites W1966299416 @default.
- W2883485382 cites W1969218538 @default.
- W2883485382 cites W1983782630 @default.
- W2883485382 cites W1986427539 @default.
- W2883485382 cites W2030292647 @default.
- W2883485382 cites W2035774172 @default.
- W2883485382 cites W2052207335 @default.
- W2883485382 cites W2073132779 @default.
- W2883485382 cites W2075269227 @default.
- W2883485382 cites W2076340825 @default.
- W2883485382 cites W2077149270 @default.
- W2883485382 cites W2081877186 @default.
- W2883485382 cites W2096770070 @default.
- W2883485382 cites W2102296058 @default.
- W2883485382 cites W2103992594 @default.
- W2883485382 cites W2106522343 @default.
- W2883485382 cites W2108813485 @default.
- W2883485382 cites W2116152286 @default.
- W2883485382 cites W2124067321 @default.
- W2883485382 cites W2126447662 @default.
- W2883485382 cites W2129715930 @default.
- W2883485382 cites W2144902263 @default.
- W2883485382 cites W2152076520 @default.
- W2883485382 cites W2155802193 @default.
- W2883485382 cites W2158734363 @default.
- W2883485382 cites W2168666392 @default.
- W2883485382 cites W2236650526 @default.
- W2883485382 cites W2253358758 @default.
- W2883485382 cites W2259389884 @default.
- W2883485382 cites W2343314930 @default.
- W2883485382 cites W2344740792 @default.
- W2883485382 cites W2345513470 @default.
- W2883485382 cites W2502823729 @default.
- W2883485382 cites W2541841360 @default.
- W2883485382 cites W2562970611 @default.
- W2883485382 cites W2564361602 @default.
- W2883485382 cites W2579523860 @default.
- W2883485382 cites W2588086300 @default.
- W2883485382 cites W2606044283 @default.
- W2883485382 cites W2607100304 @default.
- W2883485382 cites W2608540100 @default.
- W2883485382 cites W2616989718 @default.
- W2883485382 cites W2624564619 @default.
- W2883485382 cites W2697639812 @default.
- W2883485382 cites W2752691536 @default.
- W2883485382 cites W2762025761 @default.
- W2883485382 cites W2764308423 @default.
- W2883485382 cites W2793377167 @default.
- W2883485382 cites W2796140702 @default.
- W2883485382 cites W2803663595 @default.
- W2883485382 cites W2810037834 @default.
- W2883485382 cites W2811140389 @default.
- W2883485382 cites W4231286510 @default.
- W2883485382 cites W585575935 @default.
- W2883485382 doi "https://doi.org/10.1016/j.smim.2018.07.003" @default.
- W2883485382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30041831" @default.
- W2883485382 hasPublicationYear "2018" @default.
- W2883485382 type Work @default.
- W2883485382 sameAs 2883485382 @default.
- W2883485382 citedByCount "38" @default.
- W2883485382 countsByYear W28834853822018 @default.
- W2883485382 countsByYear W28834853822019 @default.
- W2883485382 countsByYear W28834853822020 @default.
- W2883485382 countsByYear W28834853822021 @default.
- W2883485382 countsByYear W28834853822022 @default.
- W2883485382 countsByYear W28834853822023 @default.
- W2883485382 crossrefType "journal-article" @default.
- W2883485382 hasAuthorship W2883485382A5010371900 @default.
- W2883485382 hasAuthorship W2883485382A5030631117 @default.
- W2883485382 hasAuthorship W2883485382A5069089383 @default.
- W2883485382 hasBestOaLocation W28834853821 @default.
- W2883485382 hasConcept C116675565 @default.
- W2883485382 hasConcept C159047783 @default.
- W2883485382 hasConcept C203014093 @default.
- W2883485382 hasConcept C22070199 @default.
- W2883485382 hasConcept C2522874641 @default.
- W2883485382 hasConcept C2777469322 @default.
- W2883485382 hasConcept C2778190748 @default.
- W2883485382 hasConcept C2778933410 @default.
- W2883485382 hasConcept C2779057330 @default.
- W2883485382 hasConcept C2779341262 @default.
- W2883485382 hasConcept C2909623084 @default.
- W2883485382 hasConcept C71924100 @default.
- W2883485382 hasConcept C86803240 @default.
- W2883485382 hasConcept C8891405 @default.
- W2883485382 hasConceptScore W2883485382C116675565 @default.
- W2883485382 hasConceptScore W2883485382C159047783 @default.