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• W2883503439 endingPage "24" @default.
• W2883503439 startingPage "18" @default.
• W2883503439 abstract "Diabetes is a chronic metabolic disease characterized by hyperglycemia and several associated biochemical abnormalities. Diabetes leads to multiorgan complications that collectively reduce life expectancy. Hematopoietic stem cells (HSCs) are nested within bone marrow (BM) niches whence they can be mobilized to the peripheral circulation. Clinically, this is done for HSC collection and autologous or allogenic transplantation. A great amount of data from basic and clinical studies support that diabetic patients are poor HSC mobilizers owing to BM remodeling. Dysfunction of the BM shares pathophysiological features and pathways with typical chronic diabetic complications that affect other issues (e.g. the retina and the kidney). From a clinical perspective, impaired HSC mobilization translates into the failure to collect a minimum number of CD34+ cells to achieve a safe engraftment after transplantation. Furthermore, blunted mobilization is associated with reduced steady-state levels of circulating HSCs, which have been consistently described in diabetic patients and associated with increased risk of adverse outcomes, including cardiovascular events and death. In this review, we discuss the most clinically relevant pharmacological options to overcome impaired HSC mobilization in diabetes. These therapeutic strategies may result in an improved outcome of diabetic patients undergoing HSC transplantation and restore circulating HSC levels, thereby protecting from adverse cardiovascular outcomes." @default.
• W2883503439 created "2018-08-03" @default.
• W2883503439 creator A5027393457 @default.
• W2883503439 creator A5045364954 @default.
• W2883503439 date "2018-09-01" @default.
• W2883503439 modified "2023-09-25" @default.
• W2883503439 title "Pharmacologic targeting of the diabetic stem cell mobilopathy" @default.
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• W2883503439 doi "https://doi.org/10.1016/j.phrs.2018.07.017" @default.
• W2883503439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30030170" @default.
• W2883503439 hasPublicationYear "2018" @default.
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