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- W2883555895 abstract "Mechanistic details for the roles of sphingolipids and their downstream targets in the regulation of tumor growth, response to chemo/radiotherapy, and metastasis have been investigated in recent studies using innovative molecular, genetic and pharmacologic tools in various cancer models. Induction of ceramide generation in response to cellular stress by chemotherapy, radiation, or exogenous ceramide analog drugs mediates cell death via apoptosis, necroptosis, or mitophagy. In this chapter, distinct functions and mechanisms of action of endogenous ceramides with different fatty acyl chain lengths in the regulation of cancer cell death versus survival will be discussed. In addition, importance of ceramide subcellular localization, trafficking, and lipid-protein binding between ceramide and various target proteins in cancer cells will be reviewed. Moreover, clinical trials from structure-function-based studies to restore antiproliferative ceramide signaling by activating ceramide synthesis will also be analyzed. Future studies are important to understand the mechanistic involvement of ceramide-mediated cell death in anticancer therapy, including immunotherapy." @default.
- W2883555895 created "2018-08-03" @default.
- W2883555895 creator A5011733159 @default.
- W2883555895 creator A5020959452 @default.
- W2883555895 creator A5074525368 @default.
- W2883555895 date "2018-01-01" @default.
- W2883555895 modified "2023-10-16" @default.
- W2883555895 title "Mechanisms of Ceramide-Dependent Cancer Cell Death" @default.
- W2883555895 cites W1024647727 @default.
- W2883555895 cites W1142459305 @default.
- W2883555895 cites W1490506267 @default.
- W2883555895 cites W1524055105 @default.
- W2883555895 cites W1555026559 @default.
- W2883555895 cites W1880491872 @default.
- W2883555895 cites W1900480423 @default.
- W2883555895 cites W1966452335 @default.
- W2883555895 cites W1970504457 @default.
- W2883555895 cites W1970962289 @default.
- W2883555895 cites W1976101319 @default.
- W2883555895 cites W1977644244 @default.
- W2883555895 cites W1978051650 @default.
- W2883555895 cites W1978918501 @default.
- W2883555895 cites W1981224101 @default.
- W2883555895 cites W1990115856 @default.
- W2883555895 cites W2000987281 @default.
- W2883555895 cites W2001956269 @default.
- W2883555895 cites W2009373735 @default.
- W2883555895 cites W2011153884 @default.
- W2883555895 cites W2013331682 @default.
- W2883555895 cites W2017214859 @default.
- W2883555895 cites W2017729786 @default.
- W2883555895 cites W2021635600 @default.
- W2883555895 cites W2022589671 @default.
- W2883555895 cites W2024817554 @default.
- W2883555895 cites W2027151723 @default.
- W2883555895 cites W2028956758 @default.
- W2883555895 cites W2036292773 @default.
- W2883555895 cites W2037202221 @default.
- W2883555895 cites W2041254182 @default.
- W2883555895 cites W2044126507 @default.
- W2883555895 cites W2049691632 @default.
- W2883555895 cites W2050704037 @default.
- W2883555895 cites W2052250480 @default.
- W2883555895 cites W2052926053 @default.
- W2883555895 cites W2060612001 @default.
- W2883555895 cites W2068444709 @default.
- W2883555895 cites W2070607918 @default.
- W2883555895 cites W2071733232 @default.
- W2883555895 cites W2073115843 @default.
- W2883555895 cites W2073647995 @default.
- W2883555895 cites W2076226373 @default.
- W2883555895 cites W2078520816 @default.
- W2883555895 cites W2079559417 @default.
- W2883555895 cites W2082046754 @default.
- W2883555895 cites W2090483851 @default.
- W2883555895 cites W2091536410 @default.
- W2883555895 cites W2092574884 @default.
- W2883555895 cites W2104511328 @default.
- W2883555895 cites W2104948944 @default.
- W2883555895 cites W2106160782 @default.
- W2883555895 cites W2111196144 @default.
- W2883555895 cites W2111563286 @default.
- W2883555895 cites W2119764013 @default.
- W2883555895 cites W2120078064 @default.
- W2883555895 cites W2122834752 @default.
- W2883555895 cites W2122855165 @default.
- W2883555895 cites W2124473191 @default.
- W2883555895 cites W2126505325 @default.
- W2883555895 cites W2126762040 @default.
- W2883555895 cites W2126762891 @default.
- W2883555895 cites W2131811820 @default.
- W2883555895 cites W2134197723 @default.
- W2883555895 cites W2134810505 @default.
- W2883555895 cites W2138459238 @default.
- W2883555895 cites W2139753251 @default.
- W2883555895 cites W2140855654 @default.
- W2883555895 cites W2141347249 @default.
- W2883555895 cites W2145662953 @default.
- W2883555895 cites W2145876349 @default.
- W2883555895 cites W2149643028 @default.
- W2883555895 cites W2150339227 @default.
- W2883555895 cites W2151340435 @default.
- W2883555895 cites W2156164763 @default.
- W2883555895 cites W2158353135 @default.
- W2883555895 cites W2160506865 @default.
- W2883555895 cites W2165197006 @default.
- W2883555895 cites W2167649159 @default.
- W2883555895 cites W2170406693 @default.
- W2883555895 cites W2171162411 @default.
- W2883555895 cites W2172662470 @default.
- W2883555895 cites W2191007858 @default.
- W2883555895 cites W2227925477 @default.
- W2883555895 cites W2255975777 @default.
- W2883555895 cites W2265704217 @default.
- W2883555895 cites W2290316348 @default.
- W2883555895 cites W2304229185 @default.
- W2883555895 cites W2305786969 @default.
- W2883555895 cites W2306229455 @default.