Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883560814> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2883560814 endingPage "15" @default.
- W2883560814 startingPage "11" @default.
- W2883560814 abstract "This review summarizes our work on the process development for synthesis of amontidineremantadine. The presented publications have been sorted according to five basic criteria. Influenza is a serious infectious disease, which is life-threatening especially in children, seniors and immunocompromised patients. In addition to vaccination, the development of new anti-influenza agents represents a crucial defense strategy to combat seasonal and pandemic influenza strains. At present most attention is paid to the development of inhibitors of influenza neuraminidase, which has been established as a key drug target for the prophylaxis and treatment of influenza infections. However, the emergence of drug-resistant influenza variants highlights the need of continuously innovative strategies for the development of new drugs with improved antiviral effects, higher safety and increased tolerability. The M2 proton channel of the Influenza A virus is the target of the anti-influenza drugs amantadine and rimantadine. The effectiveness of these drugs has been dramatically limited by the rapid spread of drug resistant mutations, mainly at sites S31N, V27A and L26F in the pore of the channel. Despite progress in designing inhibitors of V27A and L26F M2, there are currently no drugs targeting these mutated channels in clinical trials. The article traces the evolution of various synthesis approaches and provides a comparison for overall yield efficiency. Amantadine hydrochloride is an antiviral drug used in prevention and treatment of influenza A infections. It has also been used for alleviating early symptoms of Parkinson’s disease. Several methods for the preparation of Amantadine hydrochloride have been reported overall yields ranging from 50% to 52%. In this article, we describe procedure for the synthesis of Amantadine hydrochloride from N-(1-adamantyl)acetamide with an improved yield of 60%. The procedure was also optimized to reduce the use of toxic solvents and reagents, rendering it more environmentfriendly. The procedure can be considered as suitable for large-scale production of amantadine hydrochloride." @default.
- W2883560814 created "2018-08-03" @default.
- W2883560814 creator A5023265286 @default.
- W2883560814 date "2018-01-01" @default.
- W2883560814 modified "2023-09-23" @default.
- W2883560814 title "Recent advances in process development of antiviral agents targeting the influenza virus: Amantadine-Remantadine-derived pharmaceutical agents." @default.
- W2883560814 hasPublicationYear "2018" @default.
- W2883560814 type Work @default.
- W2883560814 sameAs 2883560814 @default.
- W2883560814 citedByCount "0" @default.
- W2883560814 crossrefType "journal-article" @default.
- W2883560814 hasAuthorship W2883560814A5023265286 @default.
- W2883560814 hasConcept C134164806 @default.
- W2883560814 hasConcept C159047783 @default.
- W2883560814 hasConcept C177713679 @default.
- W2883560814 hasConcept C197934379 @default.
- W2883560814 hasConcept C2522874641 @default.
- W2883560814 hasConcept C2777374534 @default.
- W2883560814 hasConcept C2777546802 @default.
- W2883560814 hasConcept C2778375690 @default.
- W2883560814 hasConcept C2779756493 @default.
- W2883560814 hasConcept C2780035454 @default.
- W2883560814 hasConcept C2780391423 @default.
- W2883560814 hasConcept C64903051 @default.
- W2883560814 hasConcept C71924100 @default.
- W2883560814 hasConcept C98274493 @default.
- W2883560814 hasConceptScore W2883560814C134164806 @default.
- W2883560814 hasConceptScore W2883560814C159047783 @default.
- W2883560814 hasConceptScore W2883560814C177713679 @default.
- W2883560814 hasConceptScore W2883560814C197934379 @default.
- W2883560814 hasConceptScore W2883560814C2522874641 @default.
- W2883560814 hasConceptScore W2883560814C2777374534 @default.
- W2883560814 hasConceptScore W2883560814C2777546802 @default.
- W2883560814 hasConceptScore W2883560814C2778375690 @default.
- W2883560814 hasConceptScore W2883560814C2779756493 @default.
- W2883560814 hasConceptScore W2883560814C2780035454 @default.
- W2883560814 hasConceptScore W2883560814C2780391423 @default.
- W2883560814 hasConceptScore W2883560814C64903051 @default.
- W2883560814 hasConceptScore W2883560814C71924100 @default.
- W2883560814 hasConceptScore W2883560814C98274493 @default.
- W2883560814 hasIssue "2" @default.
- W2883560814 hasLocation W28835608141 @default.
- W2883560814 hasOpenAccess W2883560814 @default.
- W2883560814 hasPrimaryLocation W28835608141 @default.
- W2883560814 hasRelatedWork W1586714751 @default.
- W2883560814 hasRelatedWork W198643845 @default.
- W2883560814 hasRelatedWork W2010574696 @default.
- W2883560814 hasRelatedWork W2016029520 @default.
- W2883560814 hasRelatedWork W2043580251 @default.
- W2883560814 hasRelatedWork W2052287941 @default.
- W2883560814 hasRelatedWork W2058290736 @default.
- W2883560814 hasRelatedWork W2083790241 @default.
- W2883560814 hasRelatedWork W2139633093 @default.
- W2883560814 hasRelatedWork W2190953437 @default.
- W2883560814 hasRelatedWork W2323985106 @default.
- W2883560814 hasRelatedWork W233802631 @default.
- W2883560814 hasRelatedWork W2416238607 @default.
- W2883560814 hasRelatedWork W2470149646 @default.
- W2883560814 hasRelatedWork W2947242124 @default.
- W2883560814 hasRelatedWork W3011440028 @default.
- W2883560814 hasRelatedWork W3011918196 @default.
- W2883560814 hasRelatedWork W2154030535 @default.
- W2883560814 hasRelatedWork W2778876086 @default.
- W2883560814 hasRelatedWork W2927736837 @default.
- W2883560814 hasVolume "2" @default.
- W2883560814 isParatext "false" @default.
- W2883560814 isRetracted "false" @default.
- W2883560814 magId "2883560814" @default.
- W2883560814 workType "article" @default.