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- W2883593721 abstract "Abstract Disruption of persistent, stress-associated memories is relevant for treating posttraumatic stress disorder (PTSD) and related syndromes, which develop in a subset of individuals following a traumatic event. Using a stress-enhanced fear learning protocol that results in differential susceptibility in inbred mice, we integrated small-RNA sequencing with quantitative proteomics on basolateral amygdala tissue collected one month after training. We identified persistently changed microRNAs, including mir-135b-5p, and predicted target proteins associated with PTSD-like heightened fear expression. Functional manipulations of mir-135b-5p bidirectionally modulated stress-associated memory. mir-135b-5p is expressed in human amygdala and its passenger strand was elevated in serum from a well-characterized military PTSD cohort. miR-135b-5p is a therapeutic target for dampening persistent, stress-enhanced memory and its passenger strand a potential biomarker for responsivity to a mir-135-based therapeutic. One Sentence Summary mir-135 can be manipulated to weaken persistent, stress-associated memory and serve as a biomarker of PTSD." @default.
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- W2883593721 date "2018-07-28" @default.
- W2883593721 modified "2023-09-27" @default.
- W2883593721 title "microRNA regulation of persistent stress-enhanced memory" @default.
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- W2883593721 doi "https://doi.org/10.1101/379594" @default.
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