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- W2883600545 abstract "Abstract The influence of HDL3 on phospholipid breakdown was examined in human skin fibroblasts. HDL3 elicited phosphatidylcholine (PC) and phosphatidylinositol (PI) turnover and activated multiple phospholipases. In [14C]lyso-PC–labeled or [14C]choline (Cho)-labeled cells, a biphasic activation of PC-specific phospholipase D (PLD) with peak maxima 30 to 60 seconds and 5 to 7 minutes after stimulation with 20 μg/mL HDL3 was shown by (1) a 1.5- to 3-fold increase in [14C]phosphatidic acid (PA), (2) a 1.6-fold increase in Cho release, and (3) transphosphatidylation of PC to phosphatidylbutanol in the presence of 0.3% butanol. Activation of PC-specific PLD was paralleled by an activation of PC-specific phospholipase C (PLC). A significant increase in [14C]diacylglycerol (DG) was seen from 2 minutes after stimulation onward and remained for at least 2 hours. By means of butanol, the PA-phosphohydrolase (PPH) inhibitor propranolol, and the PC-PLC inhibitor D609, we demonstrated that the initial PC-derived DG f..." @default.
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- W2883600545 date "1995-11-01" @default.
- W2883600545 modified "2023-09-26" @default.
- W2883600545 title "HDL3 Stimulates Multiple Signaling Pathways in Human Skin Fibroblasts" @default.
- W2883600545 hasPublicationYear "1995" @default.
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