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• W2883644976 abstract "Metabolomics refers to top-down systems biological analysis of metabolites in biological specimens. Phenotypic proximity of metabolites makes them interesting candidates for studying biomarkers of environmental stressors such as parasitic infections. Moreover, the host-parasite interaction directly impinges upon metabolic pathways since the parasite uses the host metabolite pool as a biosynthetic resource. Malarial infection, although not recognized as a classic metabolic disorder, often leads to severe metabolic changes such as hypoglycemia and lactic acidosis. Thus, metabolomic analysis of the infection has become an invaluable tool for promoting a better understanding of the host-parasite interaction and for the development of novel therapeutics. In this review, we summarize the current knowledge obtained from metabolomic studies of malarial infection in rodent models and human patients. Metabolomic analysis of experimental rodent malaria has provided significant insights into the mechanisms of disease progression including utilization of host resources by the parasite, sexual dimorphism in metabolic phenotypes, and cellular changes in host metabolism. Moreover, these studies also provide proof of concept for prediction of cerebral malaria. On the other hand, metabolite analysis of patient biofluids generates extensive data that could be of use in identifying biomarkers of infection severity and in monitoring disease progression. Through the use of metabolomic datasets one hopes to assess crucial infection-specific issues such as clinical severity, drug resistance, therapeutic targets, and biomarkers. Also discussed are nascent or newly emerging areas of metabolomics such as pre-erythrocytic stages of the infection and the host immune response. This review is organized in four broad sections-methodologies for metabolomic analysis, rodent infection models, studies of human clinical specimens, and potential of immunometabolomics. Data summarized in this review should serve as a springboard for novel hypothesis testing and lead to a better understanding of malarial infection and parasite biology." @default.
• W2883644976 created "2018-08-03" @default.
• W2883644976 creator A5007769890 @default.
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• W2883644976 creator A5019679277 @default.
• W2883644976 creator A5068323156 @default.
• W2883644976 creator A5079331432 @default.
• W2883644976 date "2018-12-01" @default.
• W2883644976 modified "2023-09-26" @default.
• W2883644976 title "Metabolomic changes in vertebrate host during malaria disease progression" @default.
• W2883644976 cites W111278151 @default.
• W2883644976 cites W125803354 @default.
• W2883644976 cites W1452079913 @default.
• W2883644976 cites W1509760985 @default.
• W2883644976 cites W1541620413 @default.
• W2883644976 cites W1768569514 @default.
• W2883644976 cites W1806817314 @default.
• W2883644976 cites W1820161030 @default.
• W2883644976 cites W1881405764 @default.
• W2883644976 cites W1961061296 @default.
• W2883644976 cites W1968038275 @default.
• W2883644976 cites W1968128566 @default.
• W2883644976 cites W1969694448 @default.
• W2883644976 cites W1970140452 @default.
• W2883644976 cites W1970937149 @default.
• W2883644976 cites W1973821892 @default.
• W2883644976 cites W1975525980 @default.
• W2883644976 cites W1976282831 @default.
• W2883644976 cites W1977041255 @default.
• W2883644976 cites W1977852231 @default.
• W2883644976 cites W1981148241 @default.
• W2883644976 cites W1998806549 @default.
• W2883644976 cites W2000029446 @default.
• W2883644976 cites W2007872346 @default.
• W2883644976 cites W2010680706 @default.
• W2883644976 cites W2016808620 @default.
• W2883644976 cites W2017298747 @default.
• W2883644976 cites W2019851585 @default.
• W2883644976 cites W2021747383 @default.
• W2883644976 cites W2024088832 @default.
• W2883644976 cites W2024295937 @default.
• W2883644976 cites W2025844875 @default.
• W2883644976 cites W2026804604 @default.
• W2883644976 cites W2028840184 @default.
• W2883644976 cites W2031185073 @default.
• W2883644976 cites W2033783179 @default.
• W2883644976 cites W2035528560 @default.
• W2883644976 cites W2037350416 @default.
• W2883644976 cites W2037937299 @default.
• W2883644976 cites W2038121339 @default.
• W2883644976 cites W2042617232 @default.
• W2883644976 cites W2049512200 @default.
• W2883644976 cites W2050055399 @default.
• W2883644976 cites W2051366884 @default.
• W2883644976 cites W2063690115 @default.
• W2883644976 cites W2063874036 @default.
• W2883644976 cites W2064987052 @default.
• W2883644976 cites W2065888192 @default.
• W2883644976 cites W2072263054 @default.
• W2883644976 cites W2073132533 @default.
• W2883644976 cites W2074320074 @default.
• W2883644976 cites W2076471618 @default.
• W2883644976 cites W2077191721 @default.
• W2883644976 cites W2077449299 @default.
• W2883644976 cites W2079348110 @default.
• W2883644976 cites W2079515425 @default.
• W2883644976 cites W2083280521 @default.
• W2883644976 cites W2085667287 @default.
• W2883644976 cites W2086108438 @default.
• W2883644976 cites W2093285833 @default.
• W2883644976 cites W2094951825 @default.
• W2883644976 cites W2095134469 @default.
• W2883644976 cites W2095434093 @default.
• W2883644976 cites W2096023665 @default.
• W2883644976 cites W2097931820 @default.
• W2883644976 cites W2103615574 @default.
• W2883644976 cites W2109104657 @default.
• W2883644976 cites W2111179758 @default.
• W2883644976 cites W2114296160 @default.
• W2883644976 cites W2114302232 @default.
• W2883644976 cites W2114546524 @default.
• W2883644976 cites W2114807898 @default.
• W2883644976 cites W2115692181 @default.
• W2883644976 cites W2116022454 @default.
• W2883644976 cites W2116402706 @default.
• W2883644976 cites W2118687689 @default.
• W2883644976 cites W2118846793 @default.
• W2883644976 cites W2119171159 @default.
• W2883644976 cites W2125915621 @default.
• W2883644976 cites W2129973987 @default.
• W2883644976 cites W2130185238 @default.
• W2883644976 cites W2131835194 @default.
• W2883644976 cites W2135591814 @default.
• W2883644976 cites W2136309056 @default.
• W2883644976 cites W2137062868 @default.
• W2883644976 cites W2140829266 @default.
• W2883644976 cites W2142060065 @default.
• W2883644976 cites W2142600698 @default.

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