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• W2883669424 abstract "Abstract Background We have recently found a potential protective effect of beta‐blockers on oropharyngeal dysphagia ( OD ). The action mechanism by which beta‐blockers could wield this protective effect is unknown, but the neurotransmitter substance P ( SP ) could play a key role. The aim of this study was to analyze serum and saliva SP levels in patients taking beta‐blockers ( TBB ), and to explore its relationship with OD . Methods Adult (>50 year) patients TBB were randomly recruited from the primary care setting and 1:1 matched by age, sex, and Barthel Index ( BI ) with patients not taking beta‐blockers ( NTBB ). Serum and saliva samples were taken and analyzed for their SP levels using an enzyme‐linked immunosorbent assay ( ELISA ). Socio‐demographic and clinical variables were collected. Dysphagia was evaluated in all patients using the clinical volume‐viscosity swallow test (V‐ VST ). Key Results We studied 28 patients TBB (64.96 ± 7.31 years, 57.1% women, BI 99.6 ± 1.31, carvedilol‐equivalent dose 24.11 ± 18.12 mg) and 28 patients NTBB (65.61 ± 6.43 years, 57.1% women, BI 99.6 ± 1.31). SP serum levels were significantly higher in patients TBB (260.68 ± 144.27 vs 175.46 ± 108.36 pg/mL, P = .009) as were SP saliva levels (170.34 ± 146.48 vs 102.73 ± 52.28 pg/mL, P < .001) compared with patients NTBB. The prevalence of OD was 32.1% in patients TBB and 67.9% in patients NTBB ( P = .015). Moreover, patients with OD had significantly lower SP saliva levels in comparison with patients without clinical signs of OD (98.39 ± 43.25 vs 174.69 ± 147.21 pg/mL) P < .001. Conclusions & Inferences We have found that serum and saliva SP levels are greater in patients TBB . This increase in SP levels could be the action mechanism by which beta‐blockers protect patients from OD ." @default.
• W2883669424 created "2018-08-03" @default.
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• W2883669424 date "2018-07-24" @default.
• W2883669424 modified "2023-09-26" @default.
• W2883669424 title "Increased levels of substance P in patients taking beta-blockers are linked with a protective effect on oropharyngeal dysphagia" @default.
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• W2883669424 doi "https://doi.org/10.1111/nmo.13397" @default.
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• W2883669424 hasPublicationYear "2018" @default.
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