FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883669502> ?p ?o ?g. }

• W2883669502 endingPage "11" @default.
• W2883669502 startingPage "1" @default.
• W2883669502 abstract "Purpose. To further validate the prognostic power of the biomarker PDE4D7, we investigated the correlation of PDE4D7 scores adjusted for presurgical clinical variables with longitudinal postsurgical biological outcomes. Methods. RNA was extracted from biopsy punches of resected tumors (550 patients; RP cohort) and diagnostic needle biopsies (168 patients; DB cohort). Cox regression and survival were applied to correlate PDE4D7 scores with patient outcomes. Logistic regression was used to combine the clinical CAPRA score with PDE4D7. Results. In univariate analysis, the PDE4D7 score was significantly associated with PSA recurrence after prostatectomy in both studied patient cohorts’ analysis (HR 0.53; 95% CI 0.41-0.67; p<1.0E-04 and HR 0.47; 95% CI 0.33-0.65; p<1.0E-04, respectively). After adjustment for the presurgical clinical variables preoperative PSA, PSA density, biopsy Gleason, clinical stage, percentage tumor in the biopsy (data only available for RP cohort), and percentage of positive biopsies, the HR was 0.49 (95% CI 0.38-0.64; p<1.0E-04) and 0.43 (95% CI 0.29-0.63; p<1.0E-04), respectively. The addition of the PDE4D7 to the clinical CAPRA score increased the AUC by 5% over the CAPRA score alone (0.82 versus 0.77; p=0.004). This combination model stratified 14.6% patients of the DB cohort to no risk of biochemical relapse (NPV 100%) over a follow-up period of up to 15 years. Conclusions. The PDE4D7 score provides independent risk information for pretreatment risk stratification. Combining CAPRA with PDE4D7 scores significantly improved the clinical risk stratification before surgery." @default.
• W2883669502 created "2018-08-03" @default.
• W2883669502 creator A5001534857 @default.
• W2883669502 creator A5020147142 @default.
• W2883669502 creator A5021523398 @default.
• W2883669502 creator A5024472343 @default.
• W2883669502 creator A5024801599 @default.
• W2883669502 creator A5027701585 @default.
• W2883669502 creator A5032670284 @default.
• W2883669502 creator A5040093169 @default.
• W2883669502 creator A5055792963 @default.
• W2883669502 creator A5066974526 @default.
• W2883669502 creator A5067622085 @default.
• W2883669502 creator A5069068387 @default.
• W2883669502 creator A5076196986 @default.
• W2883669502 creator A5079180984 @default.
• W2883669502 creator A5079642150 @default.
• W2883669502 creator A5088928712 @default.
• W2883669502 date "2018-07-26" @default.
• W2883669502 modified "2023-10-16" @default.
• W2883669502 title "The Prognostic PDE4D7 Score in a Diagnostic Biopsy Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes" @default.
• W2883669502 cites W1831945879 @default.
• W2883669502 cites W1919718794 @default.
• W2883669502 cites W1971080698 @default.
• W2883669502 cites W1992619337 @default.
• W2883669502 cites W2007837203 @default.
• W2883669502 cites W2027599361 @default.
• W2883669502 cites W2031163899 @default.
• W2883669502 cites W2061280839 @default.
• W2883669502 cites W2067738389 @default.
• W2883669502 cites W2074685353 @default.
• W2883669502 cites W2095740768 @default.
• W2883669502 cites W2097479331 @default.
• W2883669502 cites W2103444700 @default.
• W2883669502 cites W2107633226 @default.
• W2883669502 cites W2131970968 @default.
• W2883669502 cites W2150634191 @default.
• W2883669502 cites W2166339706 @default.
• W2883669502 cites W2166692714 @default.
• W2883669502 cites W2224702980 @default.
• W2883669502 cites W2226880313 @default.
• W2883669502 cites W2336856317 @default.
• W2883669502 cites W2343105990 @default.
• W2883669502 cites W2519802255 @default.
• W2883669502 cites W2521946386 @default.
• W2883669502 cites W2523396458 @default.
• W2883669502 cites W2530483548 @default.
• W2883669502 cites W2562503140 @default.
• W2883669502 cites W2624801557 @default.
• W2883669502 cites W3023426042 @default.
• W2883669502 cites W818411473 @default.
• W2883669502 doi "https://doi.org/10.1155/2018/5821616" @default.
• W2883669502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6083737" @default.
• W2883669502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30147955" @default.
• W2883669502 hasPublicationYear "2018" @default.
• W2883669502 type Work @default.
• W2883669502 sameAs 2883669502 @default.
• W2883669502 citedByCount "8" @default.
• W2883669502 countsByYear W28836695022019 @default.
• W2883669502 countsByYear W28836695022022 @default.
• W2883669502 countsByYear W28836695022023 @default.
• W2883669502 crossrefType "journal-article" @default.
• W2883669502 hasAuthorship W2883669502A5001534857 @default.
• W2883669502 hasAuthorship W2883669502A5020147142 @default.
• W2883669502 hasAuthorship W2883669502A5021523398 @default.
• W2883669502 hasAuthorship W2883669502A5024472343 @default.
• W2883669502 hasAuthorship W2883669502A5024801599 @default.
• W2883669502 hasAuthorship W2883669502A5027701585 @default.
• W2883669502 hasAuthorship W2883669502A5032670284 @default.
• W2883669502 hasAuthorship W2883669502A5040093169 @default.
• W2883669502 hasAuthorship W2883669502A5055792963 @default.
• W2883669502 hasAuthorship W2883669502A5066974526 @default.
• W2883669502 hasAuthorship W2883669502A5067622085 @default.
• W2883669502 hasAuthorship W2883669502A5069068387 @default.
• W2883669502 hasAuthorship W2883669502A5076196986 @default.
• W2883669502 hasAuthorship W2883669502A5079180984 @default.
• W2883669502 hasAuthorship W2883669502A5079642150 @default.
• W2883669502 hasAuthorship W2883669502A5088928712 @default.
• W2883669502 hasBestOaLocation W28836695021 @default.
• W2883669502 hasConcept C121608353 @default.
• W2883669502 hasConcept C126322002 @default.
• W2883669502 hasConcept C143998085 @default.
• W2883669502 hasConcept C144301174 @default.
• W2883669502 hasConcept C151956035 @default.
• W2883669502 hasConcept C2775934546 @default.
• W2883669502 hasConcept C2779466945 @default.
• W2883669502 hasConcept C2780192828 @default.
• W2883669502 hasConcept C38180746 @default.
• W2883669502 hasConcept C50382708 @default.
• W2883669502 hasConcept C71924100 @default.
• W2883669502 hasConcept C72563966 @default.
• W2883669502 hasConceptScore W2883669502C121608353 @default.
• W2883669502 hasConceptScore W2883669502C126322002 @default.
• W2883669502 hasConceptScore W2883669502C143998085 @default.
• W2883669502 hasConceptScore W2883669502C144301174 @default.
• W2883669502 hasConceptScore W2883669502C151956035 @default.
• W2883669502 hasConceptScore W2883669502C2775934546 @default.
• W2883669502 hasConceptScore W2883669502C2779466945 @default.

• next