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- W2883670085 abstract "Objective: In a proportion of patients with cervical lymph node metastasis no primary can be found even with modern imaging and careful clinical examination (cancer of unknown primary syndrome = CUP syndrome). The ideal diagnostic approach is still debated on.Methods: The clinical data of 75 patients (median age: 61.8 years; 16 females and 59 males), which have been treated for cervical squamous cell carcinoma of unknown primary syndrome in our hospital were retrospectively analyzed.Results: In 12% of patients (n = 9) the primary demarcated in a time period of up to 5.3 years after diagnosis. In the patients who did not receive adjuvant radiotherapy (n = 13), primary became apparent in 38%. Diagnostic lymph node extirpation delayed time until therapeutic neck dissection on average for 3 weeks. In 62% of patients with previous lymph node extirpation (pN2a–N2c), a modified radical neck dissection was required compared to 41% when the surgical site was not operated on.Conclusions: In 12% of patients’ primary demarcated in the course of the disease. A diagnostic lymph node extirpation was compared to direct therapeutic neck dissection after frozen section analysis associated with a three weeks delayed therapy and higher rate of modified radical neck dissection." @default.
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- W2883670085 date "2018-07-17" @default.
- W2883670085 modified "2023-10-14" @default.
- W2883670085 title "Diagnostic lymph node extirpation in CUP syndrome – useful or damaging?" @default.
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- W2883670085 doi "https://doi.org/10.1080/00016489.2018.1484563" @default.
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