FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883670451> ?p ?o ?g. }

• W2883670451 abstract "Abstract NC-8 (ent-16-oxobeyeran-19-N-methylureido) is an isosteviol-derived analogue with multiple biological effects, including anti-inflammation and anti-bacterial activities and inhibition of HBV viral surface antigen gene expression. In this study, we explored the effects of NC-8 on the formation of osteoclasts from RAW 264.7 cells. We found that NC-8 exerts the novel effect of inhibiting osteoclast-like cell formation. Our experiments showed that RANKL-induced ERK, p38, and JNK phosphorylation were inhibited by NC-8. An ovariectomy-induced osteoporosis animal model was used to examine the protective effects of oral treatment with NC-8. Serum analysis was used to examine markers of osteoblasts, osteoclasts, and renal and hepatic function in rats. Micro CT scanning and histological analysis were used to measure bone loss in ovariectomized rats. Oral administration of NC-8 effectively decreased excess bone resorption and significantly antagonized trabecular bone loss in ovariectomized rats. Serum analysis of C-terminal telopeptide of type-I collagen, an osteoclast marker, also showed that NC-8 administration inhibited excess bone resorption. Furthermore, serum analysis showed that renal and liver function were not affected by these doses of NC-8 during long-term treatment. Our results demonstrate that NC-8 inhibits osteoclast differentiation and effectively ameliorates ovariectomy-induced osteoporosis." @default.
• W2883670451 created "2018-08-03" @default.
• W2883670451 creator A5003401750 @default.
• W2883670451 creator A5004109147 @default.
• W2883670451 creator A5004695493 @default.
• W2883670451 creator A5012172900 @default.
• W2883670451 creator A5021780864 @default.
• W2883670451 creator A5027725935 @default.
• W2883670451 creator A5038610896 @default.
• W2883670451 creator A5041289344 @default.
• W2883670451 creator A5091772794 @default.
• W2883670451 date "2018-07-25" @default.
• W2883670451 modified "2023-10-11" @default.
• W2883670451 title "Isosteviol Derivative Inhibits Osteoclast Differentiation and Ameliorates Ovariectomy-Induced Osteoporosis" @default.
• W2883670451 cites W1488095102 @default.
• W2883670451 cites W1555132893 @default.
• W2883670451 cites W1842557142 @default.
• W2883670451 cites W1974530844 @default.
• W2883670451 cites W1993812666 @default.
• W2883670451 cites W1995147873 @default.
• W2883670451 cites W2022351216 @default.
• W2883670451 cites W2024631639 @default.
• W2883670451 cites W2032097545 @default.
• W2883670451 cites W2033208175 @default.
• W2883670451 cites W2043055703 @default.
• W2883670451 cites W2045532799 @default.
• W2883670451 cites W2056965311 @default.
• W2883670451 cites W2064346787 @default.
• W2883670451 cites W2066749771 @default.
• W2883670451 cites W2075633105 @default.
• W2883670451 cites W2079173609 @default.
• W2883670451 cites W2085536927 @default.
• W2883670451 cites W2097592282 @default.
• W2883670451 cites W2100376124 @default.
• W2883670451 cites W2110826367 @default.
• W2883670451 cites W2121836743 @default.
• W2883670451 cites W2122080830 @default.
• W2883670451 cites W2122518329 @default.
• W2883670451 cites W2131350538 @default.
• W2883670451 cites W2150799999 @default.
• W2883670451 cites W2254232426 @default.
• W2883670451 cites W2282302313 @default.
• W2883670451 cites W2330091603 @default.
• W2883670451 cites W2336810202 @default.
• W2883670451 cites W2343053274 @default.
• W2883670451 cites W2415177601 @default.
• W2883670451 cites W2592429313 @default.
• W2883670451 cites W2743868358 @default.
• W2883670451 cites W2778420431 @default.
• W2883670451 cites W2794684002 @default.
• W2883670451 cites W2794873681 @default.
• W2883670451 cites W2807151162 @default.
• W2883670451 cites W2807182156 @default.
• W2883670451 cites W2810796779 @default.
• W2883670451 cites W2923685508 @default.
• W2883670451 doi "https://doi.org/10.1038/s41598-018-29257-1" @default.
• W2883670451 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6060097" @default.
• W2883670451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30046042" @default.
• W2883670451 hasPublicationYear "2018" @default.
• W2883670451 type Work @default.
• W2883670451 sameAs 2883670451 @default.
• W2883670451 citedByCount "4" @default.
• W2883670451 countsByYear W28836704512018 @default.
• W2883670451 countsByYear W28836704512021 @default.
• W2883670451 countsByYear W28836704512023 @default.
• W2883670451 crossrefType "journal-article" @default.
• W2883670451 hasAuthorship W2883670451A5003401750 @default.
• W2883670451 hasAuthorship W2883670451A5004109147 @default.
• W2883670451 hasAuthorship W2883670451A5004695493 @default.
• W2883670451 hasAuthorship W2883670451A5012172900 @default.
• W2883670451 hasAuthorship W2883670451A5021780864 @default.
• W2883670451 hasAuthorship W2883670451A5027725935 @default.
• W2883670451 hasAuthorship W2883670451A5038610896 @default.
• W2883670451 hasAuthorship W2883670451A5041289344 @default.
• W2883670451 hasAuthorship W2883670451A5091772794 @default.
• W2883670451 hasBestOaLocation W28836704511 @default.
• W2883670451 hasConcept C11960822 @default.
• W2883670451 hasConcept C125870589 @default.
• W2883670451 hasConcept C126322002 @default.
• W2883670451 hasConcept C131075544 @default.
• W2883670451 hasConcept C134018914 @default.
• W2883670451 hasConcept C146562846 @default.
• W2883670451 hasConcept C160160445 @default.
• W2883670451 hasConcept C170033053 @default.
• W2883670451 hasConcept C170493617 @default.
• W2883670451 hasConcept C181199279 @default.
• W2883670451 hasConcept C185592680 @default.
• W2883670451 hasConcept C2776033226 @default.
• W2883670451 hasConcept C2776541429 @default.
• W2883670451 hasConcept C2777164284 @default.
• W2883670451 hasConcept C2779428903 @default.
• W2883670451 hasConcept C55493867 @default.
• W2883670451 hasConcept C57074206 @default.
• W2883670451 hasConcept C673006 @default.
• W2883670451 hasConcept C71924100 @default.
• W2883670451 hasConcept C8264082 @default.
• W2883670451 hasConcept C88045685 @default.
• W2883670451 hasConceptScore W2883670451C11960822 @default.
• W2883670451 hasConceptScore W2883670451C125870589 @default.
• W2883670451 hasConceptScore W2883670451C126322002 @default.

• next