Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883687564> ?p ?o ?g. }
- W2883687564 endingPage "584" @default.
- W2883687564 startingPage "577" @default.
- W2883687564 abstract "Pancreatic lipase (PL), a key enzyme responsible for the hydrolysis of triacylglycerides in the gastrointestinal tract, has been identified as the therapeutic target for the regulation of lipid absorption. In the present study, six major constituents from a famous Chinese herbal medicine Cortex Mori Radicis (also named sangbaipi in Chinese), have been collected and their inhibitory effects on PL have been carefully investigated and well characterized by a fluorescence-based assay. The results clearly demonstrated that all tested bioactive constituents from Cortex Mori Radicis including sanggenone C (SC), sanggenone D (SD), kuwanon C (KC), kuwanon G (KG), morin and morusin displayed strong to moderate inhibitory effects towards PL with the IC50 values ranging from 0.77 μM to 20.56 μM. Further investigations on inhibition kinetics demonstrated that SC, SD, KC and KG functioned as potent and mixed inhibitors against PL-mediated 4-MU oleate hydrolysis, with the Ki values less than 5.0 μM. Furthermore, molecular docking simulations demonstrated that SD (the most potent PL inhibitor from Cortex Mori Radicis) could create strong interaction with Ser152 (the key amino acid in the catalytic triad) of PL via hydrogen bonding. All these findings provided a new powerful evidence for explaining the hypolipidemic effect of Cortex Mori Radicis, also suggested that some abundant natural compounds in this herbal medicine could be served as lead compounds for the development of new PL inhibitors." @default.
- W2883687564 created "2018-08-03" @default.
- W2883687564 creator A5008654435 @default.
- W2883687564 creator A5011257548 @default.
- W2883687564 creator A5015282914 @default.
- W2883687564 creator A5022495891 @default.
- W2883687564 creator A5036846882 @default.
- W2883687564 creator A5043073852 @default.
- W2883687564 creator A5059753443 @default.
- W2883687564 creator A5065320321 @default.
- W2883687564 creator A5082010104 @default.
- W2883687564 creator A5089050646 @default.
- W2883687564 date "2018-10-01" @default.
- W2883687564 modified "2023-10-13" @default.
- W2883687564 title "Natural constituents from Cortex Mori Radicis as new pancreatic lipase inhibitors" @default.
- W2883687564 cites W1483954977 @default.
- W2883687564 cites W1553436431 @default.
- W2883687564 cites W1559657606 @default.
- W2883687564 cites W1592869161 @default.
- W2883687564 cites W1927710737 @default.
- W2883687564 cites W1964588781 @default.
- W2883687564 cites W1998191492 @default.
- W2883687564 cites W2000847043 @default.
- W2883687564 cites W2009803502 @default.
- W2883687564 cites W2024188432 @default.
- W2883687564 cites W2026034692 @default.
- W2883687564 cites W2028980013 @default.
- W2883687564 cites W2046429206 @default.
- W2883687564 cites W2048433033 @default.
- W2883687564 cites W2050450136 @default.
- W2883687564 cites W2053539976 @default.
- W2883687564 cites W2059858120 @default.
- W2883687564 cites W2066197031 @default.
- W2883687564 cites W2073779112 @default.
- W2883687564 cites W2085521777 @default.
- W2883687564 cites W2132162317 @default.
- W2883687564 cites W2135749311 @default.
- W2883687564 cites W2143069999 @default.
- W2883687564 cites W2143514749 @default.
- W2883687564 cites W2165509477 @default.
- W2883687564 cites W2227076956 @default.
- W2883687564 cites W2244492297 @default.
- W2883687564 cites W2252284138 @default.
- W2883687564 cites W2258466302 @default.
- W2883687564 cites W2282701126 @default.
- W2883687564 cites W2320654907 @default.
- W2883687564 cites W2321544728 @default.
- W2883687564 cites W2339757366 @default.
- W2883687564 cites W2416812789 @default.
- W2883687564 cites W2488729929 @default.
- W2883687564 cites W2514310228 @default.
- W2883687564 cites W2528122878 @default.
- W2883687564 cites W2581780524 @default.
- W2883687564 cites W2606446126 @default.
- W2883687564 cites W2750602256 @default.
- W2883687564 cites W2752059618 @default.
- W2883687564 cites W2753780674 @default.
- W2883687564 cites W2754028974 @default.
- W2883687564 cites W2776833191 @default.
- W2883687564 cites W2784217485 @default.
- W2883687564 cites W2792695735 @default.
- W2883687564 cites W2803522209 @default.
- W2883687564 doi "https://doi.org/10.1016/j.bioorg.2018.07.011" @default.
- W2883687564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30032067" @default.
- W2883687564 hasPublicationYear "2018" @default.
- W2883687564 type Work @default.
- W2883687564 sameAs 2883687564 @default.
- W2883687564 citedByCount "46" @default.
- W2883687564 countsByYear W28836875642018 @default.
- W2883687564 countsByYear W28836875642019 @default.
- W2883687564 countsByYear W28836875642020 @default.
- W2883687564 countsByYear W28836875642021 @default.
- W2883687564 countsByYear W28836875642022 @default.
- W2883687564 countsByYear W28836875642023 @default.
- W2883687564 crossrefType "journal-article" @default.
- W2883687564 hasAuthorship W2883687564A5008654435 @default.
- W2883687564 hasAuthorship W2883687564A5011257548 @default.
- W2883687564 hasAuthorship W2883687564A5015282914 @default.
- W2883687564 hasAuthorship W2883687564A5022495891 @default.
- W2883687564 hasAuthorship W2883687564A5036846882 @default.
- W2883687564 hasAuthorship W2883687564A5043073852 @default.
- W2883687564 hasAuthorship W2883687564A5059753443 @default.
- W2883687564 hasAuthorship W2883687564A5065320321 @default.
- W2883687564 hasAuthorship W2883687564A5082010104 @default.
- W2883687564 hasAuthorship W2883687564A5089050646 @default.
- W2883687564 hasConcept C126322002 @default.
- W2883687564 hasConcept C169760540 @default.
- W2883687564 hasConcept C17077164 @default.
- W2883687564 hasConcept C175106660 @default.
- W2883687564 hasConcept C181199279 @default.
- W2883687564 hasConcept C185592680 @default.
- W2883687564 hasConcept C202751555 @default.
- W2883687564 hasConcept C2777348757 @default.
- W2883687564 hasConcept C2777752497 @default.
- W2883687564 hasConcept C2779697368 @default.
- W2883687564 hasConcept C55493867 @default.
- W2883687564 hasConcept C556039675 @default.
- W2883687564 hasConcept C71240020 @default.