FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883697788> ?p ?o ?g. }

• W2883697788 endingPage "28" @default.
• W2883697788 startingPage "21" @default.
• W2883697788 abstract "NSAID analgesics have found widespread use in the treatment of pain, inflammation and fever. The highly COX-2-selective NSAID etoricoxib has shown a favorable side effect profile and excellent analgesic efficacy, particularly for dental and orthodontic pain, surpassing the current standard analgesic in orthodontics, acetaminophen. However, potential side effects on the rate of orthodontic tooth movement (OTM) and cranial growth, relevant for clinical usability during orthodontic treatment, have not yet been investigated. 40 male Fischer344 rats were randomly assigned to 4 groups (n = 10) — controls receiving only 1.5 ml tap water per day by oral gavage for a total of 5 weeks (1) as well as rats receiving an additional daily normal etoricoxib dosage of 7.8 mg/kg for 3d (2) and 7d/week (3) and a high dosage of 13.1 mg/kg for 7d/week (4) with serum bioavailability assessed by liquid chromatography–mass spectrometry. After one week of premedication, the first upper left molars (M1) were moved orthodontically in anterior direction for 4 weeks using a closed NiTi coil spring (0.25N) and OTM as well as sagittal cranial growth were quantified cephalometrically by CBCT imaging at the start and end of OTM. OTM, quantified as anterior metric tipping of M1, was significantly inhibited by about 33% only in rats receiving high-dose etoricoxib 7d/week (p = 0.046) with a respective, but insignificant tendency also detectable for the normal dosages, whereas sagittal cranial growth was by tendency slightly increased with rising etoricoxib dosages, reflected by corresponding steady-state serum concentrations, confirming etoricoxib bioavailability. An etoricoxib-induced clinically relevant deceleration of OTM is not to be expected at dosage regimens used in clinical practice to treat dental or orthodontic pain in contrast to a continuously administered high dosage. Due to its favorable side effect profile and higher analgesic efficiency regarding dental and orthodontic pain, etoricoxib should be a clinically valid alternative to the current standard orthodontic analgesic acetaminophen with its associated higher risk profile." @default.
• W2883697788 created "2018-08-03" @default.
• W2883697788 creator A5028650193 @default.
• W2883697788 creator A5044177807 @default.
• W2883697788 creator A5046845369 @default.
• W2883697788 creator A5058995816 @default.
• W2883697788 creator A5065069531 @default.
• W2883697788 date "2018-11-01" @default.
• W2883697788 modified "2023-09-24" @default.
• W2883697788 title "Effects of the highly COX-2-selective analgesic NSAID etoricoxib on the rate of orthodontic tooth movement and cranial growth" @default.
• W2883697788 cites W127174028 @default.
• W2883697788 cites W1273498686 @default.
• W2883697788 cites W1984279350 @default.
• W2883697788 cites W1986383551 @default.
• W2883697788 cites W1988572351 @default.
• W2883697788 cites W1989311181 @default.
• W2883697788 cites W1993581972 @default.
• W2883697788 cites W1999251294 @default.
• W2883697788 cites W2001634679 @default.
• W2883697788 cites W2012863008 @default.
• W2883697788 cites W2021557945 @default.
• W2883697788 cites W2033466425 @default.
• W2883697788 cites W2039498153 @default.
• W2883697788 cites W2042285851 @default.
• W2883697788 cites W2049069390 @default.
• W2883697788 cites W2063496932 @default.
• W2883697788 cites W2063971720 @default.
• W2883697788 cites W2075442847 @default.
• W2883697788 cites W2080874778 @default.
• W2883697788 cites W2087484885 @default.
• W2883697788 cites W2093206422 @default.
• W2883697788 cites W2103444360 @default.
• W2883697788 cites W2106828783 @default.
• W2883697788 cites W2113702685 @default.
• W2883697788 cites W2115189126 @default.
• W2883697788 cites W2121836743 @default.
• W2883697788 cites W2126601036 @default.
• W2883697788 cites W2128638581 @default.
• W2883697788 cites W2130345799 @default.
• W2883697788 cites W2130997885 @default.
• W2883697788 cites W2133194864 @default.
• W2883697788 cites W2136588269 @default.
• W2883697788 cites W2145865643 @default.
• W2883697788 cites W2147476117 @default.
• W2883697788 cites W2150000732 @default.
• W2883697788 cites W2400498319 @default.
• W2883697788 cites W2483640248 @default.
• W2883697788 cites W2555800246 @default.
• W2883697788 cites W2564966967 @default.
• W2883697788 cites W2587959697 @default.
• W2883697788 cites W2758255104 @default.
• W2883697788 cites W2795215109 @default.
• W2883697788 cites W2799374933 @default.
• W2883697788 cites W2805087910 @default.
• W2883697788 cites W3190028774 @default.
• W2883697788 cites W4230683079 @default.
• W2883697788 cites W4245492581 @default.
• W2883697788 doi "https://doi.org/10.1016/j.aanat.2018.07.001" @default.
• W2883697788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30048759" @default.
• W2883697788 hasPublicationYear "2018" @default.
• W2883697788 type Work @default.
• W2883697788 sameAs 2883697788 @default.
• W2883697788 citedByCount "10" @default.
• W2883697788 countsByYear W28836977882018 @default.
• W2883697788 countsByYear W28836977882019 @default.
• W2883697788 countsByYear W28836977882020 @default.
• W2883697788 countsByYear W28836977882021 @default.
• W2883697788 crossrefType "journal-article" @default.
• W2883697788 hasAuthorship W2883697788A5028650193 @default.
• W2883697788 hasAuthorship W2883697788A5044177807 @default.
• W2883697788 hasAuthorship W2883697788A5046845369 @default.
• W2883697788 hasAuthorship W2883697788A5058995816 @default.
• W2883697788 hasAuthorship W2883697788A5065069531 @default.
• W2883697788 hasConcept C126322002 @default.
• W2883697788 hasConcept C162156334 @default.
• W2883697788 hasConcept C199343813 @default.
• W2883697788 hasConcept C202271784 @default.
• W2883697788 hasConcept C2776214540 @default.
• W2883697788 hasConcept C2778722691 @default.
• W2883697788 hasConcept C2779944601 @default.
• W2883697788 hasConcept C2780820201 @default.
• W2883697788 hasConcept C42219234 @default.
• W2883697788 hasConcept C71924100 @default.
• W2883697788 hasConcept C98274493 @default.
• W2883697788 hasConceptScore W2883697788C126322002 @default.
• W2883697788 hasConceptScore W2883697788C162156334 @default.
• W2883697788 hasConceptScore W2883697788C199343813 @default.
• W2883697788 hasConceptScore W2883697788C202271784 @default.
• W2883697788 hasConceptScore W2883697788C2776214540 @default.
• W2883697788 hasConceptScore W2883697788C2778722691 @default.
• W2883697788 hasConceptScore W2883697788C2779944601 @default.
• W2883697788 hasConceptScore W2883697788C2780820201 @default.
• W2883697788 hasConceptScore W2883697788C42219234 @default.
• W2883697788 hasConceptScore W2883697788C71924100 @default.
• W2883697788 hasConceptScore W2883697788C98274493 @default.
• W2883697788 hasLocation W28836977881 @default.
• W2883697788 hasLocation W28836977882 @default.
• W2883697788 hasOpenAccess W2883697788 @default.

• next