FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883700510> ?p ?o ?g. }

• W2883700510 endingPage "642" @default.
• W2883700510 startingPage "633" @default.
• W2883700510 abstract "Acute lung injury (ALI), a pulmonary inflammatory disorder, is associated with high morbidity and mortality rates. Interestingly, ALI survivors have been reported for some neurocognitive deterioration at/after discharge. However, the molecular factors behind such extra pulmonary manifestation are not clearly known. The present work was designed to investigate lung-brain cross talk in experimental mice for deciphering primary molecular factors that may be involved in ALI-mediated cognitive impairment. ALI was induced in Balb/c mice by intra-tracheal administration of either 0.1 N HCl (2 ml/kg) or LPS (1 mg/kg) as single hits or both agents were administered successively to mimic the ‘two hit’ model. Interestingly two hit-mediated ALI resulted in exaggerated inflammatory response as reflected by increased pulmonary neutrophils and inflammatory factors (TNF-α/IL-1β/IL-6). Additionally, two hits resulted in delayed resolution of lung inflammation and was coupled with persistent decline in memory, as assessed by Morris water maze test. Further, two hits elevate serum levels of TNF-α/IL-1β which was associated with compromised blood brain barrier (BBB), as evident by decreased expression of occludin/claudin-5 and consequent Evans-blue extravasation in hippocampus 1 week post injury. Finally, dexamethasone protects against the two hit mediated cognitive impairment by lowering the pro-inflammatory factors (TNF-α/IL-1β) both in lungs and blood. Overall, we report for the first time that ‘two hit’ mediated ALI cause persistent cognitive impairment in mice partly via up-regulating systemic expression of TNF-α/IL-1β that may disrupt BBB and hence the model may be a useful tool to examine the lung-brain cross-talk at the molecular level for exploring newer therapeutics." @default.
• W2883700510 created "2018-08-03" @default.
• W2883700510 creator A5003744398 @default.
• W2883700510 creator A5073294913 @default.
• W2883700510 creator A5080444742 @default.
• W2883700510 date "2018-10-01" @default.
• W2883700510 modified "2023-10-16" @default.
• W2883700510 title "Two hit induced acute lung injury impairs cognitive function in mice: A potential model to study cross talk between lung and brain" @default.
• W2883700510 cites W1541649582 @default.
• W2883700510 cites W1715236271 @default.
• W2883700510 cites W1775749144 @default.
• W2883700510 cites W1909202696 @default.
• W2883700510 cites W1923027407 @default.
• W2883700510 cites W1968634197 @default.
• W2883700510 cites W1971945224 @default.
• W2883700510 cites W1975299542 @default.
• W2883700510 cites W1983310681 @default.
• W2883700510 cites W1989126517 @default.
• W2883700510 cites W1989199068 @default.
• W2883700510 cites W1992006528 @default.
• W2883700510 cites W2000441131 @default.
• W2883700510 cites W2002846880 @default.
• W2883700510 cites W2008906556 @default.
• W2883700510 cites W2020265991 @default.
• W2883700510 cites W2025648248 @default.
• W2883700510 cites W2037092646 @default.
• W2883700510 cites W2040100166 @default.
• W2883700510 cites W2040876125 @default.
• W2883700510 cites W2042175711 @default.
• W2883700510 cites W2044090566 @default.
• W2883700510 cites W2044390268 @default.
• W2883700510 cites W2049800749 @default.
• W2883700510 cites W2051902200 @default.
• W2883700510 cites W2058555746 @default.
• W2883700510 cites W2059407857 @default.
• W2883700510 cites W2061799937 @default.
• W2883700510 cites W2061958620 @default.
• W2883700510 cites W2067246993 @default.
• W2883700510 cites W2068929498 @default.
• W2883700510 cites W2069132215 @default.
• W2883700510 cites W2076225570 @default.
• W2883700510 cites W2077201173 @default.
• W2883700510 cites W2084123893 @default.
• W2883700510 cites W2087599939 @default.
• W2883700510 cites W2092637470 @default.
• W2883700510 cites W2100516941 @default.
• W2883700510 cites W2101108802 @default.
• W2883700510 cites W2110463517 @default.
• W2883700510 cites W2112363266 @default.
• W2883700510 cites W2118234970 @default.
• W2883700510 cites W2118525371 @default.
• W2883700510 cites W2121506020 @default.
• W2883700510 cites W2125411036 @default.
• W2883700510 cites W2127503606 @default.
• W2883700510 cites W2129891782 @default.
• W2883700510 cites W2133798481 @default.
• W2883700510 cites W2135735522 @default.
• W2883700510 cites W2142556826 @default.
• W2883700510 cites W2145252529 @default.
• W2883700510 cites W2159590405 @default.
• W2883700510 cites W2169473035 @default.
• W2883700510 cites W2184363220 @default.
• W2883700510 cites W2315122172 @default.
• W2883700510 cites W2415341391 @default.
• W2883700510 cites W2617729831 @default.
• W2883700510 cites W2791082632 @default.
• W2883700510 cites W74868541 @default.
• W2883700510 doi "https://doi.org/10.1016/j.bbi.2018.07.013" @default.
• W2883700510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30026058" @default.
• W2883700510 hasPublicationYear "2018" @default.
• W2883700510 type Work @default.
• W2883700510 sameAs 2883700510 @default.
• W2883700510 citedByCount "16" @default.
• W2883700510 countsByYear W28837005102018 @default.
• W2883700510 countsByYear W28837005102019 @default.
• W2883700510 countsByYear W28837005102020 @default.
• W2883700510 countsByYear W28837005102021 @default.
• W2883700510 countsByYear W28837005102022 @default.
• W2883700510 countsByYear W28837005102023 @default.
• W2883700510 crossrefType "journal-article" @default.
• W2883700510 hasAuthorship W2883700510A5003744398 @default.
• W2883700510 hasAuthorship W2883700510A5073294913 @default.
• W2883700510 hasAuthorship W2883700510A5080444742 @default.
• W2883700510 hasConcept C118552586 @default.
• W2883700510 hasConcept C126322002 @default.
• W2883700510 hasConcept C164027704 @default.
• W2883700510 hasConcept C169900460 @default.
• W2883700510 hasConcept C172467417 @default.
• W2883700510 hasConcept C17991360 @default.
• W2883700510 hasConcept C203014093 @default.
• W2883700510 hasConcept C2776914184 @default.
• W2883700510 hasConcept C2777649898 @default.
• W2883700510 hasConcept C2777714996 @default.
• W2883700510 hasConcept C2778402981 @default.
• W2883700510 hasConcept C2779540182 @default.
• W2883700510 hasConcept C2780401358 @default.
• W2883700510 hasConcept C2781161787 @default.
• W2883700510 hasConcept C44752575 @default.

• next