FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883702908> ?p ?o ?g. }

• W2883702908 endingPage "12" @default.
• W2883702908 startingPage "1" @default.
• W2883702908 abstract "Previous report described that CHCl 3 :MeOH extract of C. chayamansa leaves and pure compounds (moretenol, moretenyl acetate, kaempferol-3,7-dimethyl ether, and 5-hydroxy-7-3′,4′-trimethoxyflavanone) showed important topical and systemic anti-inflammatory activity in acute model, as well as in vitro antimycobacterial and antiprotozoal activities. In this paper, we describe the in vivo hepatoprotective and anti-inflammatory effects of the CHCl 3 :MeOH extract in chronic model and the isolation of additional compounds (moretenone and lupeol acetate). The hepatoprotective activity was determined at 39 days using Balb/c mice with liver damage induced with an antitubercular drug (RIF/INH/PZA). The anti-inflammatory activity was evaluated in a chronic model induced with CFA and in two acute models (TPA and carrageenan). In addition, moretenone and lupeol acetate were isolated and identified by spectroscopic data. Lupeol acetate is a main compound present in fractions 14-42, and this fraction was the majority fraction from the extract; from this moretenone was obtained. In animals with liver damage, the extract at 200 and 400 mg/kg induced better body weight gain with respect to positive control (Silymarin); in addition, the mice that received the extract at 200 mg/kg and Silymarin exhibited slight steatosis; however, the animals’ livers at 400 mg/kg did not show steatosis. The extract and fractions 14-42 showed a good anti-inflammatory activity by TPA model (DE 50 = 1.58 and 1.48 mg/ear) and by carrageenan model (DE 50 = 351.53 and 50.11 mg/kg). In the chronic inflammatory test, the extract at three doses revealed a similar effect to that of phenylbutazone, although the body weight gain was better in animals that received the extract at 900 mg/kg. Conclusion . The CHCl 3 :MeOH extract showed significant anti-inflammatory and good hepatoprotective effect on chronic models. The fraction containing moretenone and lupeol acetate as main compounds was more active than extract in both acute models of inflammation." @default.
• W2883702908 created "2018-08-03" @default.
• W2883702908 creator A5006557592 @default.
• W2883702908 creator A5029822974 @default.
• W2883702908 creator A5039487174 @default.
• W2883702908 creator A5053267889 @default.
• W2883702908 creator A5056033913 @default.
• W2883702908 creator A5070677942 @default.
• W2883702908 date "2018-07-25" @default.
• W2883702908 modified "2023-10-15" @default.
• W2883702908 title "Hepatoprotective and Anti-Inflammatory Activities of the<i>Cnidoscolus chayamansa</i>(Mc Vaugh) Leaf Extract in Chronic Models" @default.
• W2883702908 cites W1590457525 @default.
• W2883702908 cites W1605524457 @default.
• W2883702908 cites W1750690213 @default.
• W2883702908 cites W1969360633 @default.
• W2883702908 cites W1973707277 @default.
• W2883702908 cites W1986022889 @default.
• W2883702908 cites W2025895232 @default.
• W2883702908 cites W2027578388 @default.
• W2883702908 cites W2030430398 @default.
• W2883702908 cites W2033480290 @default.
• W2883702908 cites W2043280050 @default.
• W2883702908 cites W2059989679 @default.
• W2883702908 cites W2091750770 @default.
• W2883702908 cites W2106213552 @default.
• W2883702908 cites W2120080994 @default.
• W2883702908 cites W2130947739 @default.
• W2883702908 cites W2591085756 @default.
• W2883702908 cites W2793334183 @default.
• W2883702908 doi "https://doi.org/10.1155/2018/3896517" @default.
• W2883702908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6083640" @default.
• W2883702908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30147729" @default.
• W2883702908 hasPublicationYear "2018" @default.
• W2883702908 type Work @default.
• W2883702908 sameAs 2883702908 @default.
• W2883702908 citedByCount "10" @default.
• W2883702908 countsByYear W28837029082019 @default.
• W2883702908 countsByYear W28837029082020 @default.
• W2883702908 countsByYear W28837029082021 @default.
• W2883702908 crossrefType "journal-article" @default.
• W2883702908 hasAuthorship W2883702908A5006557592 @default.
• W2883702908 hasAuthorship W2883702908A5029822974 @default.
• W2883702908 hasAuthorship W2883702908A5039487174 @default.
• W2883702908 hasAuthorship W2883702908A5053267889 @default.
• W2883702908 hasAuthorship W2883702908A5056033913 @default.
• W2883702908 hasAuthorship W2883702908A5070677942 @default.
• W2883702908 hasBestOaLocation W28837029081 @default.
• W2883702908 hasConcept C126322002 @default.
• W2883702908 hasConcept C150903083 @default.
• W2883702908 hasConcept C185592680 @default.
• W2883702908 hasConcept C207001950 @default.
• W2883702908 hasConcept C2776175330 @default.
• W2883702908 hasConcept C2777810353 @default.
• W2883702908 hasConcept C2778004101 @default.
• W2883702908 hasConcept C2779054382 @default.
• W2883702908 hasConcept C2779703632 @default.
• W2883702908 hasConcept C2779782153 @default.
• W2883702908 hasConcept C2781227287 @default.
• W2883702908 hasConcept C55493867 @default.
• W2883702908 hasConcept C556039675 @default.
• W2883702908 hasConcept C71924100 @default.
• W2883702908 hasConcept C86803240 @default.
• W2883702908 hasConcept C98274493 @default.
• W2883702908 hasConceptScore W2883702908C126322002 @default.
• W2883702908 hasConceptScore W2883702908C150903083 @default.
• W2883702908 hasConceptScore W2883702908C185592680 @default.
• W2883702908 hasConceptScore W2883702908C207001950 @default.
• W2883702908 hasConceptScore W2883702908C2776175330 @default.
• W2883702908 hasConceptScore W2883702908C2777810353 @default.
• W2883702908 hasConceptScore W2883702908C2778004101 @default.
• W2883702908 hasConceptScore W2883702908C2779054382 @default.
• W2883702908 hasConceptScore W2883702908C2779703632 @default.
• W2883702908 hasConceptScore W2883702908C2779782153 @default.
• W2883702908 hasConceptScore W2883702908C2781227287 @default.
• W2883702908 hasConceptScore W2883702908C55493867 @default.
• W2883702908 hasConceptScore W2883702908C556039675 @default.
• W2883702908 hasConceptScore W2883702908C71924100 @default.
• W2883702908 hasConceptScore W2883702908C86803240 @default.
• W2883702908 hasConceptScore W2883702908C98274493 @default.
• W2883702908 hasFunder F4320322967 @default.
• W2883702908 hasLocation W28837029081 @default.
• W2883702908 hasLocation W28837029082 @default.
• W2883702908 hasLocation W28837029083 @default.
• W2883702908 hasLocation W28837029084 @default.
• W2883702908 hasOpenAccess W2883702908 @default.
• W2883702908 hasPrimaryLocation W28837029081 @default.
• W2883702908 hasRelatedWork W190644960 @default.
• W2883702908 hasRelatedWork W1981532440 @default.
• W2883702908 hasRelatedWork W2018075260 @default.
• W2883702908 hasRelatedWork W2165385465 @default.
• W2883702908 hasRelatedWork W2330292832 @default.
• W2883702908 hasRelatedWork W2883702908 @default.
• W2883702908 hasRelatedWork W3048330005 @default.
• W2883702908 hasRelatedWork W3132058659 @default.
• W2883702908 hasRelatedWork W3157911921 @default.
• W2883702908 hasRelatedWork W2185521739 @default.
• W2883702908 hasVolume "2018" @default.
• W2883702908 isParatext "false" @default.

• next