FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883702934> ?p ?o ?g. }

• W2883702934 endingPage "8056" @default.
• W2883702934 startingPage "8054" @default.
• W2883702934 abstract "Ever since oncologist Myles Brown used tamoxifen to treat a patient with metastatic breast cancer during his fellowship, he has wanted to understand how cancer cells can sometimes become resistant to this therapy after months of success. That quest led him to his life’s work on estrogen receptor (ER) biology. Brown has methodically pieced together the complex dance between steroid hormones such as estrogen, the receptors that bind them, and DNA. In the process, he has discovered molecules that enhance RNA transcription and uncovered the steps that lead to transcription. His goal is to contribute to novel and effective cancer therapies. His Inaugural Article (1) harnesses the power of CRISPR, a gene editing tool, not only to confirm many of his findings from the past 20 years but also to enhance understanding of the complex feedback loops between ERs, transcriptional enhancers, and genes that play a role in estrogen-positive breast cancers. Brown, the Emil Frei III Professor of Medicine at Harvard Medical School and Director of the Center for Functional Cancer Epigenetics at the Dana–Farber Cancer Institute, was elected to the National Academy of Sciences in 2016.Myles Brown. Image courtesy of the Dana–Farber Cancer Institute.Brown grew up in Bethesda, Maryland near the NIH. He lived his first five years in Massachusetts with his mother, his two brothers, and his father, who was a gynecologist. After his father died from Hodgkin’s lymphoma, his mother remarried British neurosurgeon Sydney Green and the family moved to Bethesda. The move shaped Brown’s life. In the fall of 1973, during his senior year at Walt Whitman High School, a friend who worked at the NIH told him that researcher George Khoury was looking for help. Brown had gravitated toward biology, but it was his decision to work for Khoury that provided much-needed direction. …" @default.
• W2883702934 created "2018-08-03" @default.
• W2883702934 creator A5056512650 @default.
• W2883702934 date "2018-07-23" @default.
• W2883702934 modified "2023-10-18" @default.
• W2883702934 title "Profile of Myles Brown" @default.
• W2883702934 cites W1544340619 @default.
• W2883702934 cites W1585603261 @default.
• W2883702934 cites W1802306612 @default.
• W2883702934 cites W1976619281 @default.
• W2883702934 cites W1993888034 @default.
• W2883702934 cites W2039576757 @default.
• W2883702934 cites W2129289858 @default.
• W2883702934 cites W2156933633 @default.
• W2883702934 cites W2317322771 @default.
• W2883702934 cites W2858926507 @default.
• W2883702934 doi "https://doi.org/10.1073/pnas.1810395115" @default.
• W2883702934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6094136" @default.
• W2883702934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30038006" @default.
• W2883702934 hasPublicationYear "2018" @default.
• W2883702934 type Work @default.
• W2883702934 sameAs 2883702934 @default.
• W2883702934 citedByCount "0" @default.
• W2883702934 crossrefType "journal-article" @default.
• W2883702934 hasAuthorship W2883702934A5056512650 @default.
• W2883702934 hasBestOaLocation W28837029341 @default.
• W2883702934 hasConcept C121608353 @default.
• W2883702934 hasConcept C126322002 @default.
• W2883702934 hasConcept C2777176818 @default.
• W2883702934 hasConcept C530470458 @default.
• W2883702934 hasConcept C71924100 @default.
• W2883702934 hasConceptScore W2883702934C121608353 @default.
• W2883702934 hasConceptScore W2883702934C126322002 @default.
• W2883702934 hasConceptScore W2883702934C2777176818 @default.
• W2883702934 hasConceptScore W2883702934C530470458 @default.
• W2883702934 hasConceptScore W2883702934C71924100 @default.
• W2883702934 hasIssue "32" @default.
• W2883702934 hasLocation W28837029341 @default.
• W2883702934 hasLocation W28837029342 @default.
• W2883702934 hasLocation W28837029343 @default.
• W2883702934 hasLocation W28837029344 @default.
• W2883702934 hasOpenAccess W2883702934 @default.
• W2883702934 hasPrimaryLocation W28837029341 @default.
• W2883702934 hasRelatedWork W1994711691 @default.
• W2883702934 hasRelatedWork W2011881892 @default.
• W2883702934 hasRelatedWork W2162625483 @default.
• W2883702934 hasRelatedWork W2341920515 @default.
• W2883702934 hasRelatedWork W2346048935 @default.
• W2883702934 hasRelatedWork W2359219901 @default.
• W2883702934 hasRelatedWork W2748952813 @default.
• W2883702934 hasRelatedWork W2899084033 @default.
• W2883702934 hasRelatedWork W2950036879 @default.
• W2883702934 hasRelatedWork W3136415254 @default.
• W2883702934 hasVolume "115" @default.
• W2883702934 isParatext "false" @default.
• W2883702934 isRetracted "false" @default.
• W2883702934 magId "2883702934" @default.
• W2883702934 workType "article" @default.