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• W2883703359 endingPage "1440" @default.
• W2883703359 startingPage "1430" @default.
• W2883703359 abstract "Abstract Adaptive immunity critically depends on cell migration combined with clonal selection and rapid expansion of rare lymphocytes recognising their cognate antigen in secondary lymphoid organs. It has since become apparent that large populations of T cells are maintained in tissues, which do not migrate throughout the body and do not require clonal expansion. Murine intraepithelial lymphocytes (IELs), located in the skin and small intestines, are maintained in a state of semi‐activation, in marked contrast to the quiescent condition naive and memory lymphocytes are kept in. The poised activation state of IELs, their location in the top layers of barrier organs and close bidirectional interactions with epithelial cells suggests IELs are part of a sophisticated strategy of immune‐surveillance and compartmentalisation of immune responses. Recent murine studies have reemphasised the influence of metabolism in T‐cell activation and differentiation, with different metabolic make up of naive, effector and memory T cells. Here we highlight and discuss some of the current insights on immunometabolism of IELs, with emphasis on novel data contrasting how IELs may be maintained in a semi‐activated state and may become fully functional compared with conventional T cells." @default.
• W2883703359 created "2018-08-03" @default.
• W2883703359 creator A5001127798 @default.
• W2883703359 creator A5074050880 @default.
• W2883703359 creator A5078799040 @default.
• W2883703359 creator A5082073030 @default.
• W2883703359 date "2018-08-22" @default.
• W2883703359 modified "2023-10-14" @default.
• W2883703359 title "Metabolic wiring of murine T cell and intraepithelial lymphocyte maintenance and activation" @default.
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• W2883703359 doi "https://doi.org/10.1002/eji.201646745" @default.
• W2883703359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30043974" @default.

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