FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883755573> ?p ?o ?g. }

• W2883755573 endingPage "738" @default.
• W2883755573 startingPage "731" @default.
• W2883755573 abstract "Many harmful constituents are present in e-cigarettes at much lower levels than in cigarette smoke, and the results of analysis of urinary biomarkers in e-cigarette users are consistent with these findings. However, understanding the health effects of chronic exposures to e-cigarette aerosols may require thinking beyond these comparisons. In this study, we investigated the endogenous formation of the tobacco-specific oral and esophageal carcinogen N'-nitrosonornicotine (NNN) in e-cigarette users. Salivary NNN, nornicotine, and nicotine as well as urinary tobacco biomarkers, including total NNN, were analyzed in 20 e-cigarette users, 20 smokers, and 19 nonsmokers. Nornicotine and NNN levels in e-cigarettes used by the study participants were also analyzed. The mean of NNN in saliva of e-cigarette users was 14.6 (±23.1) pg/mL, ranging from nonquantifiable (below the limit of quantitation, LOQ) to 76.0 pg/mL. In smokers, salivary NNN ranged from below LOQ to 739 pg/mL, with 80% of smokers having salivary NNN in the range of levels found in e-cigarette users. Consistent with a previous report, very low levels of urinary total NNN were present in only 5 out of 20 e-cigarette users (ranging from 0.001 to 0.01 pmol/mL urine). Only trace levels of NNN were found in e-cigarette liquids. Together, our findings demonstrate that NNN is formed endogenously in e-cigarette users. While the overall exposure to NNN in e-cigarette users is dramatically lower than in smokers, the known carcinogenic potency of NNN warrants further investigations into the potential consequences of its endogenous formation. Salivary NNN, rather than urinary total NNN, which accounts for only 1-3% of the NNN dose, should be used to monitor e-cigarette users' exposure to this carcinogen." @default.
• W2883755573 created "2018-08-03" @default.
• W2883755573 creator A5005369108 @default.
• W2883755573 creator A5005461604 @default.
• W2883755573 creator A5020118438 @default.
• W2883755573 creator A5024428580 @default.
• W2883755573 creator A5024722873 @default.
• W2883755573 creator A5050384161 @default.
• W2883755573 creator A5054433219 @default.
• W2883755573 creator A5066647065 @default.
• W2883755573 date "2018-07-18" @default.
• W2883755573 modified "2023-10-11" @default.
• W2883755573 title "Presence of the Carcinogen <i>N</i>′-Nitrosonornicotine in Saliva of E-cigarette Users" @default.
• W2883755573 cites W1775804327 @default.
• W2883755573 cites W1791842865 @default.
• W2883755573 cites W1865695329 @default.
• W2883755573 cites W1967824178 @default.
• W2883755573 cites W1968991990 @default.
• W2883755573 cites W1970425498 @default.
• W2883755573 cites W1972845367 @default.
• W2883755573 cites W1977943541 @default.
• W2883755573 cites W1998132283 @default.
• W2883755573 cites W2002874863 @default.
• W2883755573 cites W2003619392 @default.
• W2883755573 cites W2006816415 @default.
• W2883755573 cites W2023360810 @default.
• W2883755573 cites W2040610831 @default.
• W2883755573 cites W2046219406 @default.
• W2883755573 cites W2046846563 @default.
• W2883755573 cites W2058415119 @default.
• W2883755573 cites W2070611230 @default.
• W2883755573 cites W2071755029 @default.
• W2883755573 cites W2071795608 @default.
• W2883755573 cites W2097622670 @default.
• W2883755573 cites W2107337165 @default.
• W2883755573 cites W2107522684 @default.
• W2883755573 cites W2113873723 @default.
• W2883755573 cites W2121288482 @default.
• W2883755573 cites W2128456085 @default.
• W2883755573 cites W2146197660 @default.
• W2883755573 cites W2150067993 @default.
• W2883755573 cites W2151032232 @default.
• W2883755573 cites W2152024055 @default.
• W2883755573 cites W2155200622 @default.
• W2883755573 cites W2158331962 @default.
• W2883755573 cites W2159665593 @default.
• W2883755573 cites W2164800045 @default.
• W2883755573 cites W2171199301 @default.
• W2883755573 cites W2276800791 @default.
• W2883755573 cites W2297594942 @default.
• W2883755573 cites W2336924596 @default.
• W2883755573 cites W2359752640 @default.
• W2883755573 cites W2511733242 @default.
• W2883755573 cites W2512491620 @default.
• W2883755573 cites W2543647088 @default.
• W2883755573 cites W2572856188 @default.
• W2883755573 cites W2588327440 @default.
• W2883755573 cites W2594514058 @default.
• W2883755573 doi "https://doi.org/10.1021/acs.chemrestox.8b00089" @default.
• W2883755573 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8556657" @default.
• W2883755573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30019582" @default.
• W2883755573 hasPublicationYear "2018" @default.
• W2883755573 type Work @default.
• W2883755573 sameAs 2883755573 @default.
• W2883755573 citedByCount "48" @default.
• W2883755573 countsByYear W28837555732018 @default.
• W2883755573 countsByYear W28837555732019 @default.
• W2883755573 countsByYear W28837555732020 @default.
• W2883755573 countsByYear W28837555732021 @default.
• W2883755573 countsByYear W28837555732022 @default.
• W2883755573 countsByYear W28837555732023 @default.
• W2883755573 crossrefType "journal-article" @default.
• W2883755573 hasAuthorship W2883755573A5005369108 @default.
• W2883755573 hasAuthorship W2883755573A5005461604 @default.
• W2883755573 hasAuthorship W2883755573A5020118438 @default.
• W2883755573 hasAuthorship W2883755573A5024428580 @default.
• W2883755573 hasAuthorship W2883755573A5024722873 @default.
• W2883755573 hasAuthorship W2883755573A5050384161 @default.
• W2883755573 hasAuthorship W2883755573A5054433219 @default.
• W2883755573 hasAuthorship W2883755573A5066647065 @default.
• W2883755573 hasBestOaLocation W28837555732 @default.
• W2883755573 hasConcept C114246631 @default.
• W2883755573 hasConcept C126322002 @default.
• W2883755573 hasConcept C185592680 @default.
• W2883755573 hasConcept C2776166849 @default.
• W2883755573 hasConcept C2778355491 @default.
• W2883755573 hasConcept C2779547902 @default.
• W2883755573 hasConcept C2780026642 @default.
• W2883755573 hasConcept C2993351451 @default.
• W2883755573 hasConcept C3019085024 @default.
• W2883755573 hasConcept C31903555 @default.
• W2883755573 hasConcept C42407357 @default.
• W2883755573 hasConcept C504460877 @default.
• W2883755573 hasConcept C55493867 @default.
• W2883755573 hasConcept C71924100 @default.
• W2883755573 hasConcept C77411442 @default.
• W2883755573 hasConcept C99454951 @default.
• W2883755573 hasConceptScore W2883755573C114246631 @default.

• next