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- W2883802901 abstract "Heparinoid is commonly used for the treatment of superficial thrombophlebitis, a condition wherein inflammation and clotting occurs in the veins below the skin surface. However, stratum corneum is a major barrier that limits the delivery of hydrophilic heparinoid, in and across the skin. The aim of the present study was to develop a nonirritant topical formulation for heparinoid incorporating chemical penetration enhancers and investigate the delivery of heparinoid across the human epidermis using in vitro vertical Franz diffusion cells. The developed oil-in-water nanoemulsions (NEs; NE-1 and NE-2) delivered higher amount of heparinoid (91.58 ± 25.75 μg/sq.cm and 62.67 ± 5.66 μg/sq.cm, respectively) after 72 h compared with the other developed formulations, which in turn also delivered significantly higher amount compared with commercial formulations: cream (1.78 ± 0.07 μg/sq.cm), ointment (9.95 ± 4.41 μg/sq.cm), and gel (0 μg/sq.cm) (p <0.05). Transmission electron microscopy, polarizing light microscopy, and dynamic light scattering studies were performed to characterize the microstructure of these NEs with chemical enhancers. NE-1 was tested to be nonirritant with cell viability greater than 50% and a minimal release of IL-1α by using the “in vitro Epiderm tissue” model. Our results demonstrate that NE formulations represent a potential strategy for providing a localized therapy for the treatment of superficial thrombophlebitis." @default.
- W2883802901 created "2018-08-03" @default.
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- W2883802901 date "2018-11-01" @default.
- W2883802901 modified "2023-09-30" @default.
- W2883802901 title "Formulation Development and Characterization of Nanoemulsion-Based Formulation for Topical Delivery of Heparinoid" @default.
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- W2883802901 doi "https://doi.org/10.1016/j.xphs.2018.07.015" @default.
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