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- W2883844562 abstract "Abstract Objective To compare accuracy of detecting high‐grade cervical lesions (squamous intraepithelial lesions or greater, HSIL +) by high‐risk HPV messenger RNA (hr HPV ‐ RNA ) testing between physician‐ and self‐collected specimens, and by conventional cytology. Methods The present prospective longitudinal study included data collected among female sex workers ( FSW s) in Nairobi, Kenya, between December 2, 2009, and February 15, 2013. Participants self‐collected cervico‐vaginal specimens for hr HPV ‐ RNA testing, and a physician collected cervical specimens for hr HPV ‐ RNA testing and conventional cytology. hr HPV ‐ RNA testing was conducted every 3 months, and conventional cytology every 6 months. Results Overall, 350 FSW s aged 18–50 years participated. hr HPV ‐ RNA prevalence decreased slightly from 29.9% (103/344) at baseline to 24.3% (53/218) at 24 months for physician‐collected, and 28.5% (98/344) to 24.3% (53/218) for self‐collected specimens. Agreement between the sampling methods appeared to increase over time (baseline κ 0.55, 95% confidence interval [ CI ] 0.45–0.65; 24 months κ 0.83, 95% CI 0.74–0.91). Among 21 patients with HSIL + over 24 months, 18 (86%) and 17 (81%) had hr HPV ‐ RNA ‐positive results at baseline in physician‐ and self‐collected specimens, respectively; and 20 (95%) had baseline hr HPV ‐ RNA ‐positive results or cytology anomalies. Conclusion Overall agreement between physician‐ and self‐collected hr HPV ‐ RNA results was moderate and appeared to increase over time. Baseline physician‐ and self‐collected hr HPV ‐ RNA tests were similarly strong indicators of cumulative HSIL + over 24 months." @default.
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- W2883844562 date "2018-09-08" @default.
- W2883844562 modified "2023-10-17" @default.
- W2883844562 title "High‐risk <scp>HPV</scp>‐<scp>RNA</scp> screening of physician‐ and self‐collected specimens for detection of cervical lesions among female sex workers in Nairobi, Kenya" @default.
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- W2883844562 doi "https://doi.org/10.1002/ijgo.12628" @default.
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