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- W2883868108 abstract "Background and Purpose—In young animals, ischemic preconditioning protects CA1 hippocampal neurons against global ischemia. However, cerebral ischemia occurs most frequently in individuals aged ≥65 years. This study examined the protection provided by ischemic preconditioning in a population of aged (18- to 20-month-old) gerbils. Methods—One group of animals was exposed to two 1.5-minute episodes of global ischemia separated by 24 hours and followed 72 hours later by a 5-minute occlusion of both carotid arteries. A second group was given 2 episodes of preconditioning only. Two other groups were exposed to 5 minutes of ischemia or sham surgery. The animals survived 10, 30, or 60 days. Functional and histological assessments were used to determine the extent of protection. Results—Ten days after ischemia there was >80% protection of CA1 neurons in ischemic preconditioned animals compared with 6% in ischemic gerbils. Nevertheless, these preconditioned animals were impaired in open-field tests of habituation...." @default.
- W2883868108 created "2018-08-03" @default.
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- W2883868108 modified "2023-09-26" @default.
- W2883868108 title "Ischemic Preconditioning in 18- to 20-Month-Old Gerbils" @default.
- W2883868108 hasPublicationYear "1999" @default.
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