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- W2883886010 abstract "Prosthetic arterial grafts often thrombose when used to bypass diseased small arteries due to the deposition of laminated platelet thrombus. The rate of lll-Indium labelled platelet accumulation on autogenous vein, polytetra- fluoroethylene (PTFE, Gore-Tex) and double velour Dacron (Microvel) has been investigated in patients and the influence of aspirin and dipyridamole (ASA/DPM) evaluated. Two days before surgery 40 patients undergoing femoro-popliteal bypass were started randomly and double blind, on either ASA 300 mgm + DPM 75 mgm tds or placebo. One week postoperatively autologous 111-Indium labelled platelets were injected and isotope emissions over the graft and contralateral leg counted for 7 days. Graft thrombogenicity was calculated as the daily rise in the ratio of counts, graft/contralateral thigh. Three placebo and one ASA/DPM prosthetic grafts occluded prior to study. Thrombogenicity (mean ± SEM) was greatest in the Dacron grafts at 0.22 ± 0.03 on placebo (n=7) and 0.16 ± 0.03 on ASA/DPM (n=5) (p < 0.05). The effect of therapy however, was most striking in reducing thrombogenicity of PTFE grafts from 0.17 ± 0.03 (n=4) to 0.06 ± 0.01 (n=7) (p < 0.02). The thrombogenicity of 0.03 ± 0.005 was so low in the 13 vein grafts that the effect of therapy could not be determined. The 111-Indium platelet technique described may be used to quantitate in vivo platelet deposition. In man the combination of ASA/DPM reduced the rate of thrombus formation on prosthetic materials. PTFE grafts with ASA/DPM therapy most nearly approach the low thrombogenicity of vein." @default.
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- W2883886010 date "1981-01-01" @default.
- W2883886010 modified "2023-09-27" @default.
- W2883886010 title "The Influence Of Materials And Platelet Inhibition On The Thrombogenicity Of Arterial Grafts In Man" @default.
- W2883886010 doi "https://doi.org/10.1055/s-0038-1652260" @default.
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