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• W2883887112 abstract "Vitiligo is a common dermatological disorder of chronic depigmentation which is phenotypically characterized by white macules on the skin caused as a result of the systematic destruction of functional melanocytes. This review provides an overview of vitiligo, its etiopathogenesis and disease management, and also discusses the scope of network-interaction studies and polypharmacological studies in understanding vitiligo disease module. A narrative review of the relevant published literatures known to the authors that comprehensively discussed about vitiligo and its implications was conducted. Emerging evidence underlines the existing connection between deregulated miRNA function and vitiligo pathogenesis. It has also been linked with autoimmunity for the cause of melanocyte death in susceptible individuals. Alteration of genetic factors involved in immune responses and melanogenesis along with environmental factors are central to disease manifestation. Screening methods as such are not available for vitiligo, and the diagnosis is based on the assessment of the absence of melanocytes from the lesions in the affected area. With the occurrence of vitiligo at any age, most people typically develop it at a young age. Depending on the disease course and duration, clinical management primarily involves disease stabilization either by repigmentation or depigmentation of the skin. Several questions remain unsolved which indeed makes vitiligo an excellent model for studying autoimmune and degenerative processes. An understanding of the underlying degenerative mechanisms and unraveling the biological mediators of melanocyte loss will open up avenues for testing novel therapeutic approaches in vitiligo management. Such studies can revolutionize our apprehension of the molecular interconnections that underpin vitiligo pathogenesis." @default.
• W2883887112 created "2018-08-03" @default.
• W2883887112 creator A5001121325 @default.
• W2883887112 creator A5018240433 @default.
• W2883887112 date "2018-08-15" @default.
• W2883887112 modified "2023-09-23" @default.
• W2883887112 title "Exploring vitiligo susceptibility and management: a brief review" @default.
• W2883887112 cites W1501412155 @default.
• W2883887112 cites W1521858627 @default.
• W2883887112 cites W1531963242 @default.
• W2883887112 cites W1544009106 @default.
• W2883887112 cites W1597383179 @default.
• W2883887112 cites W1603966665 @default.
• W2883887112 cites W1781577325 @default.
• W2883887112 cites W1823918878 @default.
• W2883887112 cites W1837184809 @default.
• W2883887112 cites W1927105710 @default.
• W2883887112 cites W1933351899 @default.
• W2883887112 cites W1943857191 @default.
• W2883887112 cites W1972297621 @default.
• W2883887112 cites W1974204723 @default.
• W2883887112 cites W1976645450 @default.
• W2883887112 cites W1980105058 @default.
• W2883887112 cites W1982984141 @default.
• W2883887112 cites W1983805005 @default.
• W2883887112 cites W1985189467 @default.
• W2883887112 cites W1986097454 @default.
• W2883887112 cites W1988497868 @default.
• W2883887112 cites W1998985848 @default.
• W2883887112 cites W1999998706 @default.
• W2883887112 cites W2001151731 @default.
• W2883887112 cites W2006683252 @default.
• W2883887112 cites W2014975722 @default.
• W2883887112 cites W2022106700 @default.
• W2883887112 cites W2022299162 @default.
• W2883887112 cites W2024594386 @default.
• W2883887112 cites W2025405004 @default.
• W2883887112 cites W2027452552 @default.
• W2883887112 cites W2030118881 @default.
• W2883887112 cites W2032325626 @default.
• W2883887112 cites W2034021163 @default.
• W2883887112 cites W2036491546 @default.
• W2883887112 cites W2044794199 @default.
• W2883887112 cites W2045681977 @default.
• W2883887112 cites W2049727802 @default.
• W2883887112 cites W2052234755 @default.
• W2883887112 cites W2052655883 @default.
• W2883887112 cites W2055539585 @default.
• W2883887112 cites W2056144049 @default.
• W2883887112 cites W2056365441 @default.
• W2883887112 cites W2056997968 @default.
• W2883887112 cites W2059119358 @default.
• W2883887112 cites W2069384112 @default.
• W2883887112 cites W2070162139 @default.
• W2883887112 cites W2073062251 @default.
• W2883887112 cites W2076152557 @default.
• W2883887112 cites W2076832628 @default.
• W2883887112 cites W2077507123 @default.
• W2883887112 cites W2079076202 @default.
• W2883887112 cites W2087931060 @default.
• W2883887112 cites W2091048702 @default.
• W2883887112 cites W2094267710 @default.
• W2883887112 cites W2094573831 @default.
• W2883887112 cites W2096521470 @default.
• W2883887112 cites W2098687312 @default.
• W2883887112 cites W2099661483 @default.
• W2883887112 cites W2112445408 @default.
• W2883887112 cites W2112542562 @default.
• W2883887112 cites W2120744727 @default.
• W2883887112 cites W2125841481 @default.
• W2883887112 cites W2127501217 @default.
• W2883887112 cites W2129310091 @default.
• W2883887112 cites W2141665982 @default.
• W2883887112 cites W2142390919 @default.
• W2883887112 cites W2144093986 @default.
• W2883887112 cites W2145124378 @default.
• W2883887112 cites W2146388117 @default.
• W2883887112 cites W2146966558 @default.
• W2883887112 cites W2163480486 @default.
• W2883887112 cites W2164054725 @default.
• W2883887112 cites W2164304488 @default.
• W2883887112 cites W2171155602 @default.
• W2883887112 cites W2225481478 @default.
• W2883887112 cites W2263987099 @default.
• W2883887112 cites W2311205482 @default.
• W2883887112 cites W2466064491 @default.
• W2883887112 cites W2536042267 @default.
• W2883887112 cites W2626609299 @default.
• W2883887112 cites W2805374487 @default.
• W2883887112 cites W4210955641 @default.
• W2883887112 cites W4251360987 @default.
• W2883887112 cites W4253119698 @default.
• W2883887112 cites W4255696556 @default.
• W2883887112 cites W787345825 @default.
• W2883887112 doi "https://doi.org/10.1186/s41702-018-0030-y" @default.
• W2883887112 hasPublicationYear "2018" @default.
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