Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883960817> ?p ?o ?g. }
- W2883960817 endingPage "141" @default.
- W2883960817 startingPage "127" @default.
- W2883960817 abstract "Amyloid plaque–forming transgenic mice display neuronal hyperexcitability, epilepsy, and sudden deaths in early adulthood. However, it is unknown whether hyperexcitability persists until middle ages when memory impairment manifests. We recorded multichannel video electroencephalography (EEG), local field potentials, and auditory evoked potentials in transgenic mice carrying mutated human amyloid precursor protein (APP) and presenilin-1 (PS1) genes and wild-type littermates at 14–16 months and compared the results with data we have earlier collected from 4-month-old mice. Furthermore, we monitored acoustic startle responses in other APP/PS1 and wild-type mice from 3 to 11 months of age. Independent of the age APP/PS1 mice demonstrated increased cortical power at 8–60 Hz. They also displayed over 5-fold increase in the occurrence of spike-wave discharges and augmented auditory evoked potentials compared with nontransgenic littermates. In contrast to evoked potentials, APP/PS1 mice showed normalization of acoustic startle responses with aging. Increased cortical power and spike-wave discharges provide powerful new biomarkers to monitor progression of amyloid pathology in preclinical intervention studies." @default.
- W2883960817 created "2018-08-03" @default.
- W2883960817 creator A5005270668 @default.
- W2883960817 creator A5023778238 @default.
- W2883960817 creator A5053896485 @default.
- W2883960817 creator A5073207268 @default.
- W2883960817 creator A5085269217 @default.
- W2883960817 date "2018-11-01" @default.
- W2883960817 modified "2023-09-26" @default.
- W2883960817 title "Increased cortical beta power and spike-wave discharges in middle-aged APP/PS1 mice" @default.
- W2883960817 cites W1584834830 @default.
- W2883960817 cites W1629933021 @default.
- W2883960817 cites W1782567541 @default.
- W2883960817 cites W1927567505 @default.
- W2883960817 cites W1965584252 @default.
- W2883960817 cites W1968937229 @default.
- W2883960817 cites W1972850922 @default.
- W2883960817 cites W1975221291 @default.
- W2883960817 cites W1984305433 @default.
- W2883960817 cites W1986510040 @default.
- W2883960817 cites W1989407221 @default.
- W2883960817 cites W1996032190 @default.
- W2883960817 cites W2000225222 @default.
- W2883960817 cites W2004852048 @default.
- W2883960817 cites W2005719973 @default.
- W2883960817 cites W2014232846 @default.
- W2883960817 cites W2015743538 @default.
- W2883960817 cites W2032683219 @default.
- W2883960817 cites W2036979981 @default.
- W2883960817 cites W2038572225 @default.
- W2883960817 cites W2041796249 @default.
- W2883960817 cites W2044422034 @default.
- W2883960817 cites W2047062123 @default.
- W2883960817 cites W2048685634 @default.
- W2883960817 cites W2052530454 @default.
- W2883960817 cites W2052990681 @default.
- W2883960817 cites W2054961347 @default.
- W2883960817 cites W2063523175 @default.
- W2883960817 cites W2068784646 @default.
- W2883960817 cites W2076731029 @default.
- W2883960817 cites W2083317764 @default.
- W2883960817 cites W2084499843 @default.
- W2883960817 cites W2084808214 @default.
- W2883960817 cites W2087264614 @default.
- W2883960817 cites W2089760277 @default.
- W2883960817 cites W2091414943 @default.
- W2883960817 cites W2101341993 @default.
- W2883960817 cites W2111786210 @default.
- W2883960817 cites W2113915565 @default.
- W2883960817 cites W2125866101 @default.
- W2883960817 cites W2142943752 @default.
- W2883960817 cites W2145138741 @default.
- W2883960817 cites W2150279035 @default.
- W2883960817 cites W2153095386 @default.
- W2883960817 cites W2153628730 @default.
- W2883960817 cites W2159879468 @default.
- W2883960817 cites W2161924901 @default.
- W2883960817 cites W2162948131 @default.
- W2883960817 cites W2163301650 @default.
- W2883960817 cites W2164295765 @default.
- W2883960817 cites W2168312889 @default.
- W2883960817 cites W2264419512 @default.
- W2883960817 cites W2317108595 @default.
- W2883960817 cites W2337016337 @default.
- W2883960817 cites W2344567909 @default.
- W2883960817 cites W2401094336 @default.
- W2883960817 cites W2402889809 @default.
- W2883960817 cites W2527395963 @default.
- W2883960817 cites W2527558243 @default.
- W2883960817 cites W2533905828 @default.
- W2883960817 cites W2570679643 @default.
- W2883960817 cites W2599512437 @default.
- W2883960817 cites W2621079662 @default.
- W2883960817 cites W615976173 @default.
- W2883960817 cites W841048745 @default.
- W2883960817 doi "https://doi.org/10.1016/j.neurobiolaging.2018.07.009" @default.
- W2883960817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30138766" @default.
- W2883960817 hasPublicationYear "2018" @default.
- W2883960817 type Work @default.
- W2883960817 sameAs 2883960817 @default.
- W2883960817 citedByCount "16" @default.
- W2883960817 countsByYear W28839608172019 @default.
- W2883960817 countsByYear W28839608172020 @default.
- W2883960817 countsByYear W28839608172021 @default.
- W2883960817 countsByYear W28839608172022 @default.
- W2883960817 countsByYear W28839608172023 @default.
- W2883960817 crossrefType "journal-article" @default.
- W2883960817 hasAuthorship W2883960817A5005270668 @default.
- W2883960817 hasAuthorship W2883960817A5023778238 @default.
- W2883960817 hasAuthorship W2883960817A5053896485 @default.
- W2883960817 hasAuthorship W2883960817A5073207268 @default.
- W2883960817 hasAuthorship W2883960817A5085269217 @default.
- W2883960817 hasConcept C102230213 @default.
- W2883960817 hasConcept C104317684 @default.
- W2883960817 hasConcept C117838684 @default.
- W2883960817 hasConcept C141035611 @default.
- W2883960817 hasConcept C142724271 @default.
- W2883960817 hasConcept C15744967 @default.