FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883963338> ?p ?o ?g. }

• W2883963338 endingPage "1213" @default.
• W2883963338 startingPage "1208" @default.
• W2883963338 abstract "Abstract Background: Prenatal diethylstilbestrol (DES) exposure is associated with adverse reproductive outcomes and cancer of the breast and vagina/cervix in adult women. DES effects on estrogen metabolism have been hypothesized, but reproductive hormone concentrations and metabolic pathways have not been comprehensively described. Methods: Blood samples were provided by 60 postmenopausal women (40 exposed and 20 unexposed) who were participants in the NCI Combined DES Cohort Study, had never used hormone supplements or been diagnosed with cancer, had responded to the most recent cohort study questionnaire, and lived within driving distance of Boston University Medical School (Boston, MA). Parent estrogens and their metabolites were measured by high-performance liquid chromatography–tandem mass spectrometry. Age-adjusted percent changes in geometric means and associated 95% confidence intervals (CIs) between the exposed and unexposed were calculated. Results: Concentrations of total estrogens (15.3%; CI, −4.1–38.5) and parent estrogens (27.1%; CI, −8.2–76.1) were slightly higher in the DES-exposed than unexposed. Ratios of path2:parent estrogens (−36.5%; CI, −53.0 to −14.3) and path2:path16 (−28.8%; CI, −47.3–3.7) were lower in the DES exposed. These associations persisted with adjustment for total estrogen, years since menopause, body mass index, parity, and recent alcohol intake. Conclusions: These preliminary data suggest that postmenopausal women who were prenatally DES exposed may have relatively less 2 than 16 pathway estrogen metabolism compared with unexposed women. Impact: Lower 2 pathway metabolism has been associated with increased postmenopausal breast cancer risk and could potentially offer a partial explanation for the modest increased risk observed for prenatally DES-exposed women. Cancer Epidemiol Biomarkers Prev; 27(10); 1208–13. ©2018 AACR." @default.
• W2883963338 created "2018-08-03" @default.
• W2883963338 creator A5005351223 @default.
• W2883963338 creator A5039850031 @default.
• W2883963338 creator A5050414089 @default.
• W2883963338 creator A5069191858 @default.
• W2883963338 creator A5072311250 @default.
• W2883963338 creator A5084811382 @default.
• W2883963338 creator A5091654542 @default.
• W2883963338 date "2018-10-01" @default.
• W2883963338 modified "2023-10-05" @default.
• W2883963338 title "Estrogen Metabolism in Postmenopausal Women Exposed <i>In Utero</i> to Diethylstilbestrol" @default.
• W2883963338 cites W1511256976 @default.
• W2883963338 cites W1584022009 @default.
• W2883963338 cites W1968179768 @default.
• W2883963338 cites W2048587555 @default.
• W2883963338 cites W2052994025 @default.
• W2883963338 cites W2060348140 @default.
• W2883963338 cites W2086282566 @default.
• W2883963338 cites W2128133851 @default.
• W2883963338 cites W2145926321 @default.
• W2883963338 cites W2148619299 @default.
• W2883963338 cites W2166415807 @default.
• W2883963338 cites W2257991194 @default.
• W2883963338 cites W2265167920 @default.
• W2883963338 cites W2294891348 @default.
• W2883963338 cites W2562984926 @default.
• W2883963338 cites W2902914441 @default.
• W2883963338 cites W4250810471 @default.
• W2883963338 cites W2416743145 @default.
• W2883963338 doi "https://doi.org/10.1158/1055-9965.epi-18-0135" @default.
• W2883963338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6170707" @default.
• W2883963338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30049842" @default.
• W2883963338 hasPublicationYear "2018" @default.
• W2883963338 type Work @default.
• W2883963338 sameAs 2883963338 @default.
• W2883963338 citedByCount "13" @default.
• W2883963338 countsByYear W28839633382019 @default.
• W2883963338 countsByYear W28839633382020 @default.
• W2883963338 countsByYear W28839633382021 @default.
• W2883963338 countsByYear W28839633382022 @default.
• W2883963338 countsByYear W28839633382023 @default.
• W2883963338 crossrefType "journal-article" @default.
• W2883963338 hasAuthorship W2883963338A5005351223 @default.
• W2883963338 hasAuthorship W2883963338A5039850031 @default.
• W2883963338 hasAuthorship W2883963338A5050414089 @default.
• W2883963338 hasAuthorship W2883963338A5069191858 @default.
• W2883963338 hasAuthorship W2883963338A5072311250 @default.
• W2883963338 hasAuthorship W2883963338A5084811382 @default.
• W2883963338 hasAuthorship W2883963338A5091654542 @default.
• W2883963338 hasBestOaLocation W28839633381 @default.
• W2883963338 hasConcept C121608353 @default.
• W2883963338 hasConcept C126322002 @default.
• W2883963338 hasConcept C131872663 @default.
• W2883963338 hasConcept C134018914 @default.
• W2883963338 hasConcept C2777164284 @default.
• W2883963338 hasConcept C2778562196 @default.
• W2883963338 hasConcept C2780221984 @default.
• W2883963338 hasConcept C2781397067 @default.
• W2883963338 hasConcept C29456083 @default.
• W2883963338 hasConcept C42407357 @default.
• W2883963338 hasConcept C530470458 @default.
• W2883963338 hasConcept C71924100 @default.
• W2883963338 hasConcept C72563966 @default.
• W2883963338 hasConceptScore W2883963338C121608353 @default.
• W2883963338 hasConceptScore W2883963338C126322002 @default.
• W2883963338 hasConceptScore W2883963338C131872663 @default.
• W2883963338 hasConceptScore W2883963338C134018914 @default.
• W2883963338 hasConceptScore W2883963338C2777164284 @default.
• W2883963338 hasConceptScore W2883963338C2778562196 @default.
• W2883963338 hasConceptScore W2883963338C2780221984 @default.
• W2883963338 hasConceptScore W2883963338C2781397067 @default.
• W2883963338 hasConceptScore W2883963338C29456083 @default.
• W2883963338 hasConceptScore W2883963338C42407357 @default.
• W2883963338 hasConceptScore W2883963338C530470458 @default.
• W2883963338 hasConceptScore W2883963338C71924100 @default.
• W2883963338 hasConceptScore W2883963338C72563966 @default.
• W2883963338 hasFunder F4320337351 @default.
• W2883963338 hasIssue "10" @default.
• W2883963338 hasLocation W28839633381 @default.
• W2883963338 hasLocation W28839633382 @default.
• W2883963338 hasLocation W28839633383 @default.
• W2883963338 hasLocation W28839633384 @default.
• W2883963338 hasOpenAccess W2883963338 @default.
• W2883963338 hasPrimaryLocation W28839633381 @default.
• W2883963338 hasRelatedWork W1963710704 @default.
• W2883963338 hasRelatedWork W1995050400 @default.
• W2883963338 hasRelatedWork W1995647897 @default.
• W2883963338 hasRelatedWork W2013481652 @default.
• W2883963338 hasRelatedWork W2027180407 @default.
• W2883963338 hasRelatedWork W2101821182 @default.
• W2883963338 hasRelatedWork W2108578925 @default.
• W2883963338 hasRelatedWork W2109882125 @default.
• W2883963338 hasRelatedWork W2168803779 @default.
• W2883963338 hasRelatedWork W4232275671 @default.
• W2883963338 hasVolume "27" @default.
• W2883963338 isParatext "false" @default.
• W2883963338 isRetracted "false" @default.

• next