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- W2883965199 endingPage "726" @default.
- W2883965199 startingPage "715" @default.
- W2883965199 abstract "Transporters in the plasma membrane have been exploited successfully for the delivery of drugs in the form of prodrugs and nanoparticles. Organic cation/carnitine transporter 2 (OCTN2, SLC22A5) has emerged as a viable target for drug delivery. OCTN2 is a Na+-dependent high-affinity transporter for L-carnitine and a Na+-independent transporter for organic cations. OCTN2 is expressed in the blood-brain barrier, heart, liver, kidney, intestinal tract and placenta and plays an essential role in L-carnitine homeostasis in the body. Areas covered: In recent years, several studies have been reported in the literature describing the utility of OCTN2 to enhance the delivery of drugs, prodrugs and nanoparticles. Here we summarize the salient features of OCTN2 in terms of its role in the cellular uptake of its physiological substrate L-carnitine in physiological and pathological context; the structural requirements for recognition and the recent advances in OCTN2-targeted drug delivery systems, including prodrugs and nanoparticles, are discussed. Expert opinion: This transporter has great potential to be utilized as a target for drug delivery to improve oral absorption of drugs in the intestinal tract. It also has potential to facilitate the transfer of drugs across the biological barriers such as the blood-brain barrier, blood-retinal barrier, and maternal-fetal barrier." @default.
- W2883965199 created "2018-08-03" @default.
- W2883965199 creator A5009368703 @default.
- W2883965199 creator A5063211767 @default.
- W2883965199 creator A5064149402 @default.
- W2883965199 creator A5084818765 @default.
- W2883965199 creator A5091451352 @default.
- W2883965199 date "2018-07-23" @default.
- W2883965199 modified "2023-09-26" @default.
- W2883965199 title "Recent advances in drug delivery via the organic cation/carnitine transporter 2 (OCTN2/SLC22A5)" @default.
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