FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883994069> ?p ?o ?g. }

• W2883994069 endingPage "1316" @default.
• W2883994069 startingPage "1307" @default.
• W2883994069 abstract "A different molecular mechanism underlying human papilloma virus (HPV)‐negative and HPV‐active pathogenesis is responsible for better response to therapies in HPV‐associated oropharyngeal squamous cell carcinoma (OPSCC). In this study, we aim to provide an insight into molecular basis underlying this distinction and introduce possible targeted therapies for each phenotype. Using weighted gene co‐expression network analysis (WGCNA), our aim was to identify not only differentially expressed genes but also significant coexpressed gene modules responsible for genotype and phenotype distinctions between HPV‐active and HPV‐negative samples. Recognizing differentially expressed genes in each module indicates key regulators that may be ignored in an analysis only based on differential gene expression study. Two modules are investigated in detail in our analysis, related to JAK–STAT dysregulation in HPV‐negative samples, and disruption of cell fate commitment possibly induced by overexpression of BCL2 is observed in the HPV‐active cohort. The existence of differentially expressed oncogenes and potential miRNA role is investigated in our analysis. The other significant module related to keratinization, keratinocyte differentiation, and intermediate filament cytoskeleton organization was discovered in the resulting co‐expression network. A considerable number of genes was downregulated in HPV‐active samples in the relative module, postulating the impairment of cytoskeleton‐related gene expression caused by HPV intervention." @default.
• W2883994069 created "2018-08-03" @default.
• W2883994069 creator A5010573780 @default.
• W2883994069 creator A5023952101 @default.
• W2883994069 creator A5054232595 @default.
• W2883994069 creator A5055728811 @default.
• W2883994069 date "2018-07-18" @default.
• W2883994069 modified "2023-09-26" @default.
• W2883994069 title "Network based identification of different mechanisms underlying pathogenesis of human papilloma virus-active and human papilloma virus-negative oropharyngeal squamous cell carcinoma" @default.
• W2883994069 cites W1502421007 @default.
• W2883994069 cites W1778560011 @default.
• W2883994069 cites W1952507411 @default.
• W2883994069 cites W1964305071 @default.
• W2883994069 cites W1966327575 @default.
• W2883994069 cites W1969545696 @default.
• W2883994069 cites W1972655588 @default.
• W2883994069 cites W1979522770 @default.
• W2883994069 cites W1983670437 @default.
• W2883994069 cites W1991830067 @default.
• W2883994069 cites W2006778638 @default.
• W2883994069 cites W2025786205 @default.
• W2883994069 cites W2031363351 @default.
• W2883994069 cites W2033003340 @default.
• W2883994069 cites W2040002852 @default.
• W2883994069 cites W2047988468 @default.
• W2883994069 cites W2053835153 @default.
• W2883994069 cites W2060559193 @default.
• W2883994069 cites W2060705109 @default.
• W2883994069 cites W2061920911 @default.
• W2883994069 cites W2063366104 @default.
• W2883994069 cites W2067224679 @default.
• W2883994069 cites W2098282574 @default.
• W2883994069 cites W2101440362 @default.
• W2883994069 cites W2108448970 @default.
• W2883994069 cites W2108630902 @default.
• W2883994069 cites W2112534124 @default.
• W2883994069 cites W2114000644 @default.
• W2883994069 cites W2116208472 @default.
• W2883994069 cites W2122598723 @default.
• W2883994069 cites W2129265801 @default.
• W2883994069 cites W2139376220 @default.
• W2883994069 cites W2143372551 @default.
• W2883994069 cites W2143680521 @default.
• W2883994069 cites W2145821230 @default.
• W2883994069 cites W2148028028 @default.
• W2883994069 cites W2148344434 @default.
• W2883994069 cites W2161511352 @default.
• W2883994069 cites W2164367956 @default.
• W2883994069 cites W2180316168 @default.
• W2883994069 cites W2207634168 @default.
• W2883994069 cites W2267051967 @default.
• W2883994069 cites W2316606764 @default.
• W2883994069 cites W2327329538 @default.
• W2883994069 cites W2560036924 @default.
• W2883994069 cites W3099289621 @default.
• W2883994069 cites W4249273120 @default.
• W2883994069 cites W89255747 @default.
• W2883994069 doi "https://doi.org/10.1002/jccs.201800072" @default.
• W2883994069 hasPublicationYear "2018" @default.
• W2883994069 type Work @default.
• W2883994069 sameAs 2883994069 @default.
• W2883994069 citedByCount "2" @default.
• W2883994069 countsByYear W28839940692021 @default.
• W2883994069 countsByYear W28839940692023 @default.
• W2883994069 crossrefType "journal-article" @default.
• W2883994069 hasAuthorship W2883994069A5010573780 @default.
• W2883994069 hasAuthorship W2883994069A5023952101 @default.
• W2883994069 hasAuthorship W2883994069A5054232595 @default.
• W2883994069 hasAuthorship W2883994069A5055728811 @default.
• W2883994069 hasConcept C104317684 @default.
• W2883994069 hasConcept C121608353 @default.
• W2883994069 hasConcept C127716648 @default.
• W2883994069 hasConcept C142724271 @default.
• W2883994069 hasConcept C150194340 @default.
• W2883994069 hasConcept C203014093 @default.
• W2883994069 hasConcept C2522874641 @default.
• W2883994069 hasConcept C2776350393 @default.
• W2883994069 hasConcept C2778220009 @default.
• W2883994069 hasConcept C2778580637 @default.
• W2883994069 hasConcept C2780942790 @default.
• W2883994069 hasConcept C502942594 @default.
• W2883994069 hasConcept C54355233 @default.
• W2883994069 hasConcept C71924100 @default.
• W2883994069 hasConcept C86803240 @default.
• W2883994069 hasConceptScore W2883994069C104317684 @default.
• W2883994069 hasConceptScore W2883994069C121608353 @default.
• W2883994069 hasConceptScore W2883994069C127716648 @default.
• W2883994069 hasConceptScore W2883994069C142724271 @default.
• W2883994069 hasConceptScore W2883994069C150194340 @default.
• W2883994069 hasConceptScore W2883994069C203014093 @default.
• W2883994069 hasConceptScore W2883994069C2522874641 @default.
• W2883994069 hasConceptScore W2883994069C2776350393 @default.
• W2883994069 hasConceptScore W2883994069C2778220009 @default.
• W2883994069 hasConceptScore W2883994069C2778580637 @default.
• W2883994069 hasConceptScore W2883994069C2780942790 @default.
• W2883994069 hasConceptScore W2883994069C502942594 @default.
• W2883994069 hasConceptScore W2883994069C54355233 @default.
• W2883994069 hasConceptScore W2883994069C71924100 @default.

• next