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• W2884004221 endingPage "1189" @default.
• W2884004221 startingPage "1177" @default.
• W2884004221 abstract "Objectives: Psammomys obesus is a high-fat diet (HFD)-fed animal model of obesity and type 2 diabetes recently explored as a model of non-proliferative diabetic retinopathy. This study tested the protective effect of the pigment astaxanthin (AST) in the P. obesus diabetic retina.Methods: Young adult P. obesus were randomly assigned to two groups. The control group received a normal diet consisting of a plant-based regimen, and the HFD group received an enriched laboratory chow. After 3 months, control and diabetic rodents were administered vehicle or AST, daily for 7 days. Body weight, blood glucose, and plasma pentosidine were assessed. Frozen sections of retinas were immunolabeled for markers of oxidative stress, glial reactivity and retinal ganglion cell bodies, and imaged by confocal microscopy.Results: Retinal tissue from AST-treated control and HFD-diabetic P. obesus showed a greater expression of the antioxidant enzyme heme oxygenase-1 (HO-1). In retinas of HFD-diabetic AST-treated P. obesus, cellular retinaldehyde binding protein and glutamine synthetase in Müller cells were more intense compared to the untreated HFD-diabetic group. HFD-induced diabetes downregulated the expression of glial fibrillary acidic protein in astrocytes, the POU domain protein 3A in retinal ganglion cells, and synaptophysin throughout the plexiform layers.Discussion: Our results show that type 2-like diabetes induced by HFD affected glial and neuronal retinal cell homeostasis. AST treatment induced the antioxidant enzyme HO-1 and reduced glial reactivity. These findings suggest that diabetic P. obesus is a useful model of HFD-induced obesity and diabetes to evaluate early neuroglial retinal alterations and antioxidant neuroprotection mechanisms in DR." @default.
• W2884004221 created "2018-08-03" @default.
• W2884004221 creator A5039861790 @default.
• W2884004221 creator A5041713140 @default.
• W2884004221 creator A5047873646 @default.
• W2884004221 creator A5071776150 @default.
• W2884004221 date "2018-07-20" @default.
• W2884004221 modified "2023-10-18" @default.
• W2884004221 title "Short-Term Administration of Astaxanthin Attenuates Retinal Changes in Diet-Induced Diabetic <i>Psammomys obesus</i>" @default.
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• W2884004221 doi "https://doi.org/10.1080/02713683.2018.1484143" @default.
• W2884004221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30028214" @default.
• W2884004221 hasPublicationYear "2018" @default.
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