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• W2884009574 abstract "The health benefits associated to moderate wine intake have been widelyreported, however the mechanisms of protection involved in certain disorders arestill unclear. During this thesis, novel in vitro and in vivo approaches have beenapplied with the final aim of elucidating the actions of red wine and its phenolicconstituents in the management of oral diseases and brain function, as well as toevaluate the human individual metabolism in response to wine consumption.Regarding oral microbiota and health, the anti-adhesive properties of winepolyphenols against periodontal and cariogenic pathogens adherence (P. gingivalis,F. nucleatum and S. mutans) to human gingival fibroblasts have been proved, andthe evaluation of oral metabolism confirmed both, bacterial and cellular metabolismof wine polyphenols. Also, reciprocal benefits of these compounds together with arecognized oral probiotic has been revealed for the first time at oral level, as well asthe bactericidal action of red wine, dealcoholized red wine and oenological extractsagainst periodontal pathogens (P. gingivalis, F, nucleatum and A.actynomycetemcomitans) in a six-species model of subgingival biofilm.In order to characterize metabolic changes after moderate wine consumption,an untargeted metabolomics approach (UHPLC-TOF MS) has been applied to thestudy of urine samples from a human intervention study based on moderate red wineconsumption in healthy subjects. This analysis confirmed a strong impact of redwine consumption in the overall urinary metabolome, as well as biomarkersassociated to wine consumption have been proposed, including specific winecomponents (tartaric acid) and microbial-derived phenolic metabolites (γ-valerolactones and valeric acids derivatives). A stratification of the population intodifferent “metabotypes” or wine-metabolizing phenotypes has been perceiveddepending on the ability to produce specific amounts of selected bioactivecompounds. Glutaric acid derivatives, procyanidins, catechins and epicatechins, andsome microbial derived metabolites of valeric acids, were the compounds mainlyinvolved in this classification. To our knowledge, this is the first work in whichconsistent metabotypes have been described in healthy volunteers after moderatewine consumption, pointing out the value of the urinary metabolome forcharacterizing inter individual responsiveness to a dietary intervention.Abstract/Resumen4Finally, in regard to brain function, several novel and noteworthy featureshave been addressed. The study of the protective role of phenolic metabolites andaroma compounds in a situation of nitrosative-induced stress in neuroblastoma cellsconfirmed a modulation by these compounds of mitogen-activated protein kinaseroute (MAPK) as well as of caspase-3 pro-apoptotic protein expression. An in vitrocellular model of mice primary hippocampal neurons mimicking neuroticismalterations was used to explore the restoration of synaptic plasticity by winephenolic metabolites, through modulation of genes involved in protein translation.Finally, the promotion of resilient phenotype to social stress after consumption of adiet containing grape polyphenols and PMI5011 botanical extract, in a mice modelof social defeat, confirmed a positive modulation of synaptic plasticity andprevented neuroinflammation, through epigenetic mechanisms." @default.
• W2884009574 created "2018-08-03" @default.
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• W2884009574 date "2018-02-19" @default.
• W2884009574 modified "2023-09-24" @default.
• W2884009574 title "Wine polyphenols as modulators of oral microbiota in periodontitis, and neuronal dysfunction: Human metabolome and metabotyping after moderate wine consumption" @default.
• W2884009574 hasPublicationYear "2018" @default.
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