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- W2884033905 abstract "Endometriosis is a prevalent gynaecological disorder with a still unclear pathogenesis. So far inflammatory mechanisms are associated with disease progression and critical reviews have discussed the so-called ‘danger theory’ related to endometriosis. Hence, we performed immunoassays to evaluate whether local inflammation is linked to the severity of the disease. In addition, we investigated the role of recently described cytokines IL-33, IL-32α and the ‘alarmin’ high mobility group box 1 (HMGB1). We confirmed a dysfunctional immune response in the local environment of women suffering from endometriosis. However, we found no direct evidence for a significant up-regulation of danger signals in endometriosis, irrespective of the severity of the disease." @default.
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- W2884033905 date "2018-11-01" @default.
- W2884033905 modified "2023-10-16" @default.
- W2884033905 title "Local and systemic levels of cytokines and danger signals in endometriosis-affected women" @default.
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- W2884033905 doi "https://doi.org/10.1016/j.jri.2018.07.006" @default.
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