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• W2884042238 abstract "AIM AND OBJECTIVE:Reason for choosing diabetes mellitus that few medications in clinical practice forthe treatment, a hefty portion of these oral hostile to diabetic segment have been accountedfor to demonstrate genuine antagonistic side effects. It is obvious that because of thereactions of the presently utilized medications, there is a requirement for a strongmedication with negligible unfavorable impacts, which can be taken for long time. Plantmaterials which are being utilized as customary pharmaceutical for the treatment of diabetesare viewed as one of the great barriers for another medication or a prompt make anothermedication. All through the world numerous conventional plant medicines for diabetesexists. In any case, few have gotten logical or therapeutic investigation and the WHO hasprescribed that customary plant medications for diabetes warrant promote assessment andlogical approval. Presently I have under taken the investigation of Assessment ofantidiabetic of alcoholic, petroleum ether and ethyl acetate concentrates of Averrhoacarambola leaves on Streptozotocin induced diabetic rats. To meet this aim we framedfollowing objectives.OBJECTIVES: To Extract the Averrhoa carambola using different solvent by Mantox HapterTo Study the prelimmery phyto chemical screening of Averrhoe carambolaTo Evaluate the In vitro Anti diabetic study of Averrhoe carambolaTo Evaluate the In vivo Anti diabetic study of Averrhoe carambol SUMMARY:The leaf extraction was done by sequential extraction method the leaves ofAverrhoa carambola using the solvent with increasing polarity order (petroleum ether, ethylacetate and ethanol) and the active extract was tested by in vitro & in vivo antidiabeticscreening method. The in vitro antidiabetic studies have been performed based on the α-amylase inhibition assay. Each extracts were tested for α-amylase inhibition and the extractwith minimum IC50 has been undergone phyto chemical screening. The procedure wasfollowed by OECD maximum safe dose (2000mg/kg) were selected for further study. Finallythe invivo antidiabetic activity of Ethanolic extract of Averrhoa carambola leaf was tested byusing Streptozotocin induced diabetic rat. Acute toxicity study was carried out in rats. Fastingblood sample were drawn from retino orbital puncture of rats at weekly intervals till the endof the study 1,7 and 14 days. On these days fasting blood glucose were collected andanalysed for glucose. At the end of the study (14th day) the ethanolic extract of Averrhoacarambola leaf (200mg/kg p.o and 400 mg/kg p.o) treated diabetic groups showedstatistically significant decrease in blood glucose similar to the standard drug glibenclamide(2mg/kg), which indicated block the alfa amyalase activity and antagonize the Streptozotocinaction.The present study suggested that the isolation of active constituents from ethanolicextract of Averrhoa carambola leaf and characterize the compounds by using preliminaryphytochemical studies.CONCLUSION:In this current study, antidiabetic activity of both in vitro and in vivo has beenstudied for the Averrhoa carambola leaves, the ethanolic of higher concentration hasshown the increased activity as compared with the standard drug and the control.Hence, the leaves of Averrhoa carambola has got the potential hypoglycaemicactivity and can be safely used in diabetes induced animal model and it is less toxiceven at higher concentration. Hence the glucose lowering activity of this Averrhoacarambola may be utilized for the treatment of type II diabetes mellitus." @default.
• W2884042238 created "2018-08-03" @default.
• W2884042238 creator A5012437154 @default.
• W2884042238 date "2017-09-01" @default.
• W2884042238 modified "2023-09-27" @default.
• W2884042238 title "Study of Antidiabetic Activity on Averrhoa Carambola Leaves" @default.
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• W2884042238 hasPublicationYear "2017" @default.
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