FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884098295> ?p ?o ?g. }

• W2884098295 abstract "The global burden of hepatocellular carcinoma (HCC), one of the frequent causes of cancer-related deaths worldwide, is rapidly increasing partly due to the limited treatment options available for this disease and recurrence due to therapy resistance. Immune checkpoint inhibitors that are proved to be beneficial in the treatment of advanced melanoma and other cancer types are currently in clinical trials in HCC. These ongoing trials are testing the efficacy and safety of a few select checkpoints in HCC. Similar to observations in other cancers, these immune checkpoint blockade treatments as monotherapy may benefit only a fraction of HCC patients. Studies that assess the prevalence and distribution of other immune checkpoints/modulatory molecules in HCC have been limited. Moreover, robust predictors to identify which HCC patients will respond to immunotherapy are currently lacking. The objective of this study is to perform a comprehensive evaluation on different immune modulators as predictive biomarkers to monitor HCC patients at high risk for poor prognosis. We screened publically available HCC patient databases for the expression of previously well described immune checkpoint regulators and evaluated the usefulness of these immune modulators to predict high risk, patient overall survival and recurrence. We also identified the immune modulators that synergized with known immune evasion molecules programmed death receptor ligand-1 (PD-L1), programmed cell death protein-1 (PD-1), and cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and correlated with worse patient outcomes. We evaluated the association between the expression of epithelial-to-mesenchymal transition (EMT) markers and PD-L1 in HCC patient tumors. We also examined the relationship of tumor mutational burden with HCC patient survival. Notably, expression of immune modulators B7-H4, PD-L2, TIM-3, and VISTA were independently associated with worse prognosis, while B7-H4, CD73, and VISTA predicted low recurrence-free survival. Moreover, the prognosis of patients expressing high PD-L1 with high B7-H4, TIM-3, VISTA, CD73, and PD-L2 expression was significantly worse. Interestingly, PD-L1 expression in HCC patients in the high-risk group was closely associated with EMT marker expression and prognosticates poor survival. In HCC patients, high tumor mutational burden (TMB) predicted worse patient outcomes than those with low TMB." @default.
• W2884098295 created "2018-08-03" @default.
• W2884098295 creator A5004112137 @default.
• W2884098295 creator A5009499042 @default.
• W2884098295 creator A5022189861 @default.
• W2884098295 creator A5048307488 @default.
• W2884098295 creator A5057501689 @default.
• W2884098295 creator A5076911708 @default.
• W2884098295 creator A5087176957 @default.
• W2884098295 creator A5088003365 @default.
• W2884098295 date "2018-07-13" @default.
• W2884098295 modified "2023-10-11" @default.
• W2884098295 title "Monitoring Immune Checkpoint Regulators as Predictive Biomarkers in Hepatocellular Carcinoma" @default.
• W2884098295 cites W1757407923 @default.
• W2884098295 cites W1805581579 @default.
• W2884098295 cites W1855921321 @default.
• W2884098295 cites W1866166468 @default.
• W2884098295 cites W1947060780 @default.
• W2884098295 cites W1968961516 @default.
• W2884098295 cites W1971837077 @default.
• W2884098295 cites W1974059338 @default.
• W2884098295 cites W1977040692 @default.
• W2884098295 cites W1988637965 @default.
• W2884098295 cites W1992450231 @default.
• W2884098295 cites W1996863944 @default.
• W2884098295 cites W2009671859 @default.
• W2884098295 cites W2019313527 @default.
• W2884098295 cites W2029101596 @default.
• W2884098295 cites W2037915750 @default.
• W2884098295 cites W2049553585 @default.
• W2884098295 cites W2052730188 @default.
• W2884098295 cites W2066671159 @default.
• W2884098295 cites W2069220094 @default.
• W2884098295 cites W2070124928 @default.
• W2884098295 cites W2086341178 @default.
• W2884098295 cites W2097995306 @default.
• W2884098295 cites W2103950437 @default.
• W2884098295 cites W2108026478 @default.
• W2884098295 cites W2113661022 @default.
• W2884098295 cites W2114154136 @default.
• W2884098295 cites W2114843025 @default.
• W2884098295 cites W2128814129 @default.
• W2884098295 cites W2136415416 @default.
• W2884098295 cites W2138047179 @default.
• W2884098295 cites W2143163879 @default.
• W2884098295 cites W2143772132 @default.
• W2884098295 cites W2144337918 @default.
• W2884098295 cites W2152061559 @default.
• W2884098295 cites W2154589460 @default.
• W2884098295 cites W2173565120 @default.
• W2884098295 cites W2243873100 @default.
• W2884098295 cites W2256481109 @default.
• W2884098295 cites W2289712604 @default.
• W2884098295 cites W2296947286 @default.
• W2884098295 cites W2315027248 @default.
• W2884098295 cites W2329974159 @default.
• W2884098295 cites W2464194295 @default.
• W2884098295 cites W2465069352 @default.
• W2884098295 cites W2465860350 @default.
• W2884098295 cites W2474535137 @default.
• W2884098295 cites W2474747771 @default.
• W2884098295 cites W2526607882 @default.
• W2884098295 cites W2529646902 @default.
• W2884098295 cites W2534612528 @default.
• W2884098295 cites W2547094499 @default.
• W2884098295 cites W2559382297 @default.
• W2884098295 cites W2560367415 @default.
• W2884098295 cites W2572174216 @default.
• W2884098295 cites W2586232205 @default.
• W2884098295 cites W2586399611 @default.
• W2884098295 cites W2590022828 @default.
• W2884098295 cites W2591717879 @default.
• W2884098295 cites W2596245384 @default.
• W2884098295 cites W2597872842 @default.
• W2884098295 cites W2603526557 @default.
• W2884098295 cites W2605896258 @default.
• W2884098295 cites W2609799607 @default.
• W2884098295 cites W2611921638 @default.
• W2884098295 cites W2620697550 @default.
• W2884098295 cites W2747774814 @default.
• W2884098295 cites W2748476586 @default.
• W2884098295 cites W2753806822 @default.
• W2884098295 cites W2997727194 @default.
• W2884098295 cites W4243625103 @default.
• W2884098295 doi "https://doi.org/10.3389/fonc.2018.00269" @default.
• W2884098295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6053505" @default.
• W2884098295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30057891" @default.
• W2884098295 hasPublicationYear "2018" @default.
• W2884098295 type Work @default.
• W2884098295 sameAs 2884098295 @default.
• W2884098295 citedByCount "98" @default.
• W2884098295 countsByYear W28840982952018 @default.
• W2884098295 countsByYear W28840982952019 @default.
• W2884098295 countsByYear W28840982952020 @default.
• W2884098295 countsByYear W28840982952021 @default.
• W2884098295 countsByYear W28840982952022 @default.
• W2884098295 countsByYear W28840982952023 @default.
• W2884098295 crossrefType "journal-article" @default.
• W2884098295 hasAuthorship W2884098295A5004112137 @default.
• W2884098295 hasAuthorship W2884098295A5009499042 @default.

• next