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- W2884151060 endingPage "107" @default.
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- W2884151060 abstract "In nature, biological processes are regulated with precise spatial and temporal resolution at the molecular, cellular, and organismal levels. In order to perturb and manipulate these processes, optically controlled chemical tools have been developed and applied in living systems. The use of light as an external trigger provides spatial and temporal control with minimal adverse effects. Incorporation of light-responsive amino acids into proteins in cells and organisms with an expanded genetic code has enabled the precise activation/deactivation of numerous, diverse proteins, such as kinases, nucleases, proteases, and polymerases. Using unnatural amino acids to generate light-triggered proteins enables a rational engineering approach that is based on mechanistic and/or structural information. This review focuses on the most recent developments in the field, including technological advances and biological applications." @default.
- W2884151060 created "2018-08-03" @default.
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- W2884151060 date "2018-10-01" @default.
- W2884151060 modified "2023-10-17" @default.
- W2884151060 title "Recent advances in the optical control of protein function through genetic code expansion" @default.
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- W2884151060 doi "https://doi.org/10.1016/j.cbpa.2018.07.011" @default.
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