FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884204583> ?p ?o ?g. }

• W2884204583 endingPage "3352" @default.
• W2884204583 startingPage "3339" @default.
• W2884204583 abstract "Endothelin (ET)-1 is implicated in the pathophysiology of cardiovascular diseases although its role in obesity anomalies has not been fully elucidated. This study was designed to examine the impact of ET-1 receptor A (ETA) ablation on obesity-induced changes in cardiac geometry and contractile function, as well as the mechanisms involved with a focus on autophagy. Cardiomyocyte-specific ETA receptor knockout (ETAKO) and WT mice were fed either low-fat (10% calorie from fat) or high-fat (45% calorie from fat) diet for 24 weeks. Glucose tolerance test was examined to confirm insulin resistance. High-fat diet intake compromised myocardial geometry (enlarged left ventricular diameters in systole and diastole), morphology (cardiac hypertrophy, increased wall thickness and interstitial fibrosis), contractile function (reduced fractional shortening, ejection fraction and cardiomyocyte shortening) and intracellular Ca2+ handling, the effect of which was significantly attenuated by ETAKO. TUNEL staining revealed overt apoptosis in high-fat-fed group, the effect was reverted by ETAKO. Western blot analysis noted that high-fat intake downregulated leptin receptor and PPARγ, insulin signaling (elevated basal/dampened insulin-stimulated phosphorylation of Akt and IRS1), phosphorylation of AMPK, ACC, upregulated GATA-4, ANP, NFATc3, PPARα, m-TOR/p70s6k signaling, which were attenuated by ETAKO with the exception of AMPK/ACC. Furthermore, high-fat intake suppressed cardiac autophagy, which was abrogated by ETAKO. In cultured murine cardiomyocytes, palmitic acid challenged mimicked high-fat diet-induced hypertrophic and autophagic responses, the effect of which were abolished by the ETA receptor antagonist BQ123 or mTOR inhibitor rapamycin. These results suggest that inhibition of ETA rescues high-fat intake-induced cardiac anomalies possibly through autophagy regulation." @default.
• W2884204583 created "2018-08-03" @default.
• W2884204583 creator A5007706452 @default.
• W2884204583 creator A5010479652 @default.
• W2884204583 creator A5024501229 @default.
• W2884204583 creator A5032521108 @default.
• W2884204583 creator A5046557021 @default.
• W2884204583 creator A5058705371 @default.
• W2884204583 creator A5066189734 @default.
• W2884204583 creator A5074800193 @default.
• W2884204583 date "2018-10-01" @default.
• W2884204583 modified "2023-09-30" @default.
• W2884204583 title "Cardiomyocyte-specific knockout of endothelin receptor a attenuates obesity cardiomyopathy" @default.
• W2884204583 cites W1598667444 @default.
• W2884204583 cites W1968832284 @default.
• W2884204583 cites W1976902114 @default.
• W2884204583 cites W1977819697 @default.
• W2884204583 cites W1978029099 @default.
• W2884204583 cites W1983312374 @default.
• W2884204583 cites W1984111172 @default.
• W2884204583 cites W1985046929 @default.
• W2884204583 cites W1987240861 @default.
• W2884204583 cites W1987431084 @default.
• W2884204583 cites W1988092776 @default.
• W2884204583 cites W1989374806 @default.
• W2884204583 cites W2004378273 @default.
• W2884204583 cites W2010442161 @default.
• W2884204583 cites W2011014972 @default.
• W2884204583 cites W2015016880 @default.
• W2884204583 cites W2022880024 @default.
• W2884204583 cites W2035055285 @default.
• W2884204583 cites W2050153745 @default.
• W2884204583 cites W2050183926 @default.
• W2884204583 cites W2053030456 @default.
• W2884204583 cites W2053454761 @default.
• W2884204583 cites W2061785851 @default.
• W2884204583 cites W2065887259 @default.
• W2884204583 cites W2071881835 @default.
• W2884204583 cites W2075888651 @default.
• W2884204583 cites W2084207486 @default.
• W2884204583 cites W2088527201 @default.
• W2884204583 cites W2091169722 @default.
• W2884204583 cites W2099761945 @default.
• W2884204583 cites W2101701509 @default.
• W2884204583 cites W2104705785 @default.
• W2884204583 cites W2105927334 @default.
• W2884204583 cites W2107375285 @default.
• W2884204583 cites W2111163650 @default.
• W2884204583 cites W2113513087 @default.
• W2884204583 cites W2115537569 @default.
• W2884204583 cites W2118527036 @default.
• W2884204583 cites W2120863041 @default.
• W2884204583 cites W2125861412 @default.
• W2884204583 cites W2126724413 @default.
• W2884204583 cites W2151970753 @default.
• W2884204583 cites W2158404846 @default.
• W2884204583 cites W2160278781 @default.
• W2884204583 cites W2162804111 @default.
• W2884204583 cites W2170208738 @default.
• W2884204583 cites W2178028764 @default.
• W2884204583 cites W2274509164 @default.
• W2884204583 cites W2298448408 @default.
• W2884204583 cites W2303868736 @default.
• W2884204583 cites W2338550523 @default.
• W2884204583 cites W2409773562 @default.
• W2884204583 cites W2581599154 @default.
• W2884204583 cites W2617585770 @default.
• W2884204583 cites W2789727743 @default.
• W2884204583 cites W2792778713 @default.
• W2884204583 cites W2794168900 @default.
• W2884204583 cites W2800923282 @default.
• W2884204583 cites W2803897617 @default.
• W2884204583 cites W2820737565 @default.
• W2884204583 cites W2853743497 @default.
• W2884204583 doi "https://doi.org/10.1016/j.bbadis.2018.07.020" @default.
• W2884204583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30031229" @default.
• W2884204583 hasPublicationYear "2018" @default.
• W2884204583 type Work @default.
• W2884204583 sameAs 2884204583 @default.
• W2884204583 citedByCount "20" @default.
• W2884204583 countsByYear W28842045832019 @default.
• W2884204583 countsByYear W28842045832020 @default.
• W2884204583 countsByYear W28842045832021 @default.
• W2884204583 countsByYear W28842045832022 @default.
• W2884204583 countsByYear W28842045832023 @default.
• W2884204583 crossrefType "journal-article" @default.
• W2884204583 hasAuthorship W2884204583A5007706452 @default.
• W2884204583 hasAuthorship W2884204583A5010479652 @default.
• W2884204583 hasAuthorship W2884204583A5024501229 @default.
• W2884204583 hasAuthorship W2884204583A5032521108 @default.
• W2884204583 hasAuthorship W2884204583A5046557021 @default.
• W2884204583 hasAuthorship W2884204583A5058705371 @default.
• W2884204583 hasAuthorship W2884204583A5066189734 @default.
• W2884204583 hasAuthorship W2884204583A5074800193 @default.
• W2884204583 hasBestOaLocation W28842045831 @default.
• W2884204583 hasConcept C112446052 @default.
• W2884204583 hasConcept C126322002 @default.
• W2884204583 hasConcept C134018914 @default.

• next