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• W2884229780 abstract "AIM AND OBJECTIVES:Overall aim of the present work was to evaluate the protective effects of natural fruits combination against cyclophosphamide induced toxicity.The proper and regular consumption of vegetables and fruits have promising role in prevention and cure of various human diseases as well as restorative to normal health that prevent adverse effect of many medicines. Fruits are rich in vitamins, minerals and various phytonutrients. The selection of combination of fruits was made on the basis of its:Consumption of combination of fruits maintains the recommended daily allowance (RDA) of various nutrients required for our body, preventing malnutrition.Combination of fruits contains various nutraceutical and adequately supply required nutrient in excess may have synergistic effect of pharmacologically relevant natural constituents thereby promote human health and resist diseases.Degree of research work which is not yet performed using combination of fruits. DISCUSSION: The proper maintain of lifestyle-food habit play important role in control socially, mentally and physically well-being state of life. Life style diseases are one of the utmost common upsetting disease affecting millions of individuals per year around the world. In life style diseases, cancer is the most threatening and second leading cases to cause death in human-beings.The most threatening disease, cancer results from a different series of molecular altered mechanisms that essentially modify the common normal behaviour of cells in living system. The normal-healthy cells control cancer by preventing cell over-growth and the invasion of cancer cells to other tissue is restricted. Each and every disease will turn to cancer if left un-treatment for long period of time most probably, so early detection to be important for starting cancer treatment. But the treatment should not initiate till the occurrence of cancer cells is confirmed by a tissue (i.e., histologic) diagnosis. Treatment of cancer is the sequence of interventions such as psycho-social care, chemotherapy, surgical procedure and radiation therapy that is expected at curing the disease or lengthening life-time considerably while improving the patient’s quality of life. The time period of treatment schedule depends on the stage of cancer, site of cancer and its state of progression.Most of the chemotherapeutic medications are cytotoxic compounds that targeted towards rapidly growing oncogenic cells. Chemotherapy is the one of the most common option for the treatment of most of the cancers. More than 100 chemotherapy agents with altered way of mechanism are widely used, either as single form or combination therapy with other therapeutic drugs or treatments, treating specific forms of cancer.In this present work anti-cancer drug cyclophosphamide (CTX) has been used to inducing stress. In-vivo Protective activity and anti-oxidant status of natural fruits pulp formulation “FRUITITOP” was studied against administration of cyclophosphamide (CTX) in Swiss-albino mice. Cyclophosphamide, an anti-cancer alkylating agent is probably the most frequently used standard drug in cancer research field. The main metabolites of cyclophosphamide (CTX) are Acrolein and Phosphoramide. Where phosphoramide can interact with DNA and a protein by alkylation of C-7 of guanine nitrogen base, leads to formation of adducts (Balu et al., 2001). Phosphoramide mustard can cause myelo-suppression and haemorrhagic cystitis can be caused by the acrolein. The oxidative stress like loss of glutathione (GSH) and alkylation reactions at various nucleophillic sites in cell-particularly in the nucleus occur as results of high dose acrolein acute toxicity whereas, Low doses of acrolien inhibit proliferation of cells without affecting cell viability. The “FRUITITOP” treated groups were found to shown that normal range of bone marrow cellularity (BMC) and total WBC count compared to cyclophosphamide treated group, this showing the protective effect and importance of fruits consumption as a protective agent. There is no significant change in the values of haemoglobin level in all the 6 groups. It is estimated that one-third of all cancer and lifestyle disease could be prevented by improved diet, mostly improved consumption of fresh fruits, whole grains and fresh vegetables. So instead of consuming single fruits the consumption of combo of fruits will give essential nutrients, dietary anti-oxidant and different therapeutically significant nutra-ceuticals in healing and prevention of various diseases.CONCLUSION: The data obtained from current study clearly indicates that regular supply of required amount of natural fruits combination will improve the antioxidant status that can challenge the secondary challenges shown by cyclophosphamide." @default.
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• W2884229780 date "2016-10-01" @default.
• W2884229780 modified "2023-09-23" @default.
• W2884229780 title "Protective Effect of Natural Fruits Combination “Fruititop” Against Cyclophosphamide Induced Toxicity through Improving Antioxidant Status" @default.
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