FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2884231755> ?p ?o ?g. }

• W2884231755 endingPage "205873841878665" @default.
• W2884231755 startingPage "205873841878665" @default.
• W2884231755 abstract "MicroRNAs (miRNAs) as small non-coding RNAs act as either tumor suppressors or oncogenes in human cancers, of which miR-149-5p (miR-149) is involved in tumor growth and metastasis, but its role and molecular mechanisms underlying osteosarcoma growth are poorly understood. The correlation of miR-149 expression with clinicopathological characteristics and prognosis in patients with sarcoma was analyzed by The Cancer Genome Atlas (TCGA) RNA-sequencing data. Osteosarcoma cell growth affected by miR-149 was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and colony formation assays. As a result, we found that the expression level of miR-149 was markedly downregulated in human sarcoma samples and were negatively associated with tumor size, acting as an independent prognostic factor for overall survival of the sarcoma patients. Restoration of miR-149 expression suppressed osteosarcoma cell growth, while its knockdown reversed these effects. Furthermore, we identified TNFRSF12A (TNF receptor superfamily member 12A), also called fibroblast growth factor–inducible 14 (Fn14) as a direct target of miR-149, and TNFRSF12A and its ligand TNFSF12 (TNF superfamily member 12), also called tumor necrosis factor–related weak inducer of apoptosis (TWEAK), were both negatively correlated with miR-149 expression in sarcoma samples. Knockdown of TNFRSF12A suppressed cell growth, but its overexpression weakened the antiproliferative effects of miR-149 via the PI3K/AKT (AKT serine/threonine kinase) signaling pathway. Altogether, our findings show that miR-149 functions as a tumor suppressor in osteosarcoma via inhibition of the TWEAK–Fn14 axis and represents a potential therapeutic target in patients with osteosarcoma." @default.
• W2884231755 created "2018-08-03" @default.
• W2884231755 creator A5020465235 @default.
• W2884231755 creator A5050218179 @default.
• W2884231755 creator A5074437348 @default.
• W2884231755 creator A5077162836 @default.
• W2884231755 creator A5091607417 @default.
• W2884231755 date "2018-01-01" @default.
• W2884231755 modified "2023-10-01" @default.
• W2884231755 title "miR-149-5p inhibits cell growth by regulating TWEAK/Fn14/PI3K/AKT pathway and predicts favorable survival in human osteosarcoma" @default.
• W2884231755 cites W1519476263 @default.
• W2884231755 cites W1552952000 @default.
• W2884231755 cites W1622184414 @default.
• W2884231755 cites W1656255119 @default.
• W2884231755 cites W1937406958 @default.
• W2884231755 cites W1961212257 @default.
• W2884231755 cites W1964811177 @default.
• W2884231755 cites W1971054810 @default.
• W2884231755 cites W1976428580 @default.
• W2884231755 cites W1977667156 @default.
• W2884231755 cites W1991356247 @default.
• W2884231755 cites W2000190195 @default.
• W2884231755 cites W2002729585 @default.
• W2884231755 cites W200312034 @default.
• W2884231755 cites W2008061394 @default.
• W2884231755 cites W2018417370 @default.
• W2884231755 cites W2021847568 @default.
• W2884231755 cites W2023029839 @default.
• W2884231755 cites W2027230549 @default.
• W2884231755 cites W2029212902 @default.
• W2884231755 cites W2029968171 @default.
• W2884231755 cites W2034754296 @default.
• W2884231755 cites W2040703388 @default.
• W2884231755 cites W2058711347 @default.
• W2884231755 cites W2064427521 @default.
• W2884231755 cites W2083507043 @default.
• W2884231755 cites W2091807831 @default.
• W2884231755 cites W2116151287 @default.
• W2884231755 cites W2137203885 @default.
• W2884231755 cites W2144487015 @default.
• W2884231755 cites W2182551009 @default.
• W2884231755 cites W2221231509 @default.
• W2884231755 cites W2301354189 @default.
• W2884231755 cites W2335590725 @default.
• W2884231755 cites W2341392178 @default.
• W2884231755 cites W2343956211 @default.
• W2884231755 cites W2345778557 @default.
• W2884231755 cites W2410865901 @default.
• W2884231755 cites W2417668730 @default.
• W2884231755 cites W2420061955 @default.
• W2884231755 cites W2531066740 @default.
• W2884231755 cites W2628676876 @default.
• W2884231755 cites W2944703038 @default.
• W2884231755 cites W4244519238 @default.
• W2884231755 doi "https://doi.org/10.1177/2058738418786656" @default.
• W2884231755 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6050806" @default.
• W2884231755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30014744" @default.
• W2884231755 hasPublicationYear "2018" @default.
• W2884231755 type Work @default.
• W2884231755 sameAs 2884231755 @default.
• W2884231755 citedByCount "44" @default.
• W2884231755 countsByYear W28842317552019 @default.
• W2884231755 countsByYear W28842317552020 @default.
• W2884231755 countsByYear W28842317552021 @default.
• W2884231755 countsByYear W28842317552022 @default.
• W2884231755 countsByYear W28842317552023 @default.
• W2884231755 crossrefType "journal-article" @default.
• W2884231755 hasAuthorship W2884231755A5020465235 @default.
• W2884231755 hasAuthorship W2884231755A5050218179 @default.
• W2884231755 hasAuthorship W2884231755A5074437348 @default.
• W2884231755 hasAuthorship W2884231755A5077162836 @default.
• W2884231755 hasAuthorship W2884231755A5091607417 @default.
• W2884231755 hasBestOaLocation W28842317551 @default.
• W2884231755 hasConcept C104317684 @default.
• W2884231755 hasConcept C121608353 @default.
• W2884231755 hasConcept C142724271 @default.
• W2884231755 hasConcept C145059251 @default.
• W2884231755 hasConcept C173396325 @default.
• W2884231755 hasConcept C190283241 @default.
• W2884231755 hasConcept C2777760704 @default.
• W2884231755 hasConcept C2778256501 @default.
• W2884231755 hasConcept C2779013556 @default.
• W2884231755 hasConcept C502942594 @default.
• W2884231755 hasConcept C54355233 @default.
• W2884231755 hasConcept C62112901 @default.
• W2884231755 hasConcept C62478195 @default.
• W2884231755 hasConcept C71924100 @default.
• W2884231755 hasConcept C75217442 @default.
• W2884231755 hasConcept C86554907 @default.
• W2884231755 hasConcept C86803240 @default.
• W2884231755 hasConcept C95444343 @default.
• W2884231755 hasConceptScore W2884231755C104317684 @default.
• W2884231755 hasConceptScore W2884231755C121608353 @default.
• W2884231755 hasConceptScore W2884231755C142724271 @default.
• W2884231755 hasConceptScore W2884231755C145059251 @default.
• W2884231755 hasConceptScore W2884231755C173396325 @default.
• W2884231755 hasConceptScore W2884231755C190283241 @default.
• W2884231755 hasConceptScore W2884231755C2777760704 @default.

• next