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- W2884233414 endingPage "8187" @default.
- W2884233414 startingPage "8151" @default.
- W2884233414 abstract "Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide synthesis have significantly advanced developments in biological science by allowing nonspecialists to rapidly and easily access these biopolymers. Researchers have endeavored for decades to develop a comparable general automated system to synthesize oligosaccharides. Such a system would have a revolutionary impact on the understanding of the roles of glycans in biological systems. The main challenge to achieving automated synthesis is the lack of general synthetic methods for routine synthesis of glycans. Currently, the two main methods to access homogeneous glycans and glycoconjugates are chemical synthesis and enzymatic synthesis. Enzymatic glycosylation can proceed stereo- and regiospecifically without protecting group manipulations. Moreover, the reaction conditions of enzyme-catalyzed glycosylations are extremely mild when compared to chemical glycosylations. Over the past few years methodology toward the automated chemical synthesis of oligosaccharides has been developed. Conversely, while automated enzymatic synthesis is conceptually possible, it is not as well developed. The goal of this survey is to provide a foundation on which continued technological advancements can be made to promote the automated enzymatic synthesis of oligosaccharides." @default.
- W2884233414 created "2018-08-03" @default.
- W2884233414 creator A5008425019 @default.
- W2884233414 creator A5028387147 @default.
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- W2884233414 creator A5045675715 @default.
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- W2884233414 creator A5059549374 @default.
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- W2884233414 creator A5070768324 @default.
- W2884233414 creator A5081111762 @default.
- W2884233414 creator A5091200102 @default.
- W2884233414 date "2018-07-16" @default.
- W2884233414 modified "2023-10-17" @default.
- W2884233414 title "Toward Automated Enzymatic Synthesis of Oligosaccharides" @default.
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