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- W2884237051 abstract "Interferon (IFN)-λ, a type III interferon (IFN), is a member of a new family of pleotropic cytokines that share high similarity with classical IFNs α and β (IFN-α/β), type I IFNs. IFN-λ acts as an antiviral agent and displays distinct biological functions, including tumor suppression. Although it activates the common Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathways, similar to IFN-α/β, IFN-λ differentially induces the expression of IFN-stimulated genes (ISGs). Novel evidence indicates that IFN-λ acts quite differently from IFN-α/β under both homeostasis and pathological situations. In contrast to IFN-α/β, IFN-λ is not involved in over-stimulation of the immune response or exacerbation of inflammation. However, the emergence of unexpected characteristics of IFN-λ, in the control of inflammation and promotion of immune suppression and cancer, reveals novel challenges and offers more strategic opportunities in the context of cancer and beyond. In this article, we discuss new evidence and potential consequences associated with the biology of IFN-λ and provide a different vision for building novel therapeutic strategies in oncology." @default.
- W2884237051 created "2018-08-03" @default.
- W2884237051 creator A5040466212 @default.
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- W2884237051 creator A5072121808 @default.
- W2884237051 creator A5074258023 @default.
- W2884237051 creator A5075350327 @default.
- W2884237051 date "2019-01-01" @default.
- W2884237051 modified "2023-10-18" @default.
- W2884237051 title "Interferon Lambda: Toward a Dual Role in Cancer" @default.
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- W2884237051 doi "https://doi.org/10.1089/jir.2018.0046" @default.
- W2884237051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30020822" @default.
- W2884237051 hasPublicationYear "2019" @default.
- W2884237051 type Work @default.