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• W2884243985 abstract "SUMMARY Naegleria gruberi is a free-living non-pathogenic amoeboflagellate and relative of Naegleria fowleri , a deadly pathogen causing primary amoebic meningoencephalitis (PAM). A genomic analysis of N. gruberi exists, but physiological evidence for its core energy metabolism or in vivo growth substrates is lacking. Here we show that N. gruberi trophozoites need oxygen for normal functioning and growth and that they furthermore shun both glucose and amino acids as growth substrates. Trophozoite growth depends mainly upon lipid oxidation via a mitochondrial branched respiratory chain, both ends of which require oxygen as final electron acceptor. Growing N. gruberi trophozoites thus have a strictly aerobic energy metabolism with a marked substrate preference for the oxidation of fatty acids. Analyses of N. fowleri genome data and comparison with those of N. gruberi indicate that N. fowleri has the same type of metabolism. Specialization to oxygen-dependent lipid breakdown represents a hitherto unprecedented metabolic strategy in protists." @default.
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• W2884243985 date "2018-07-17" @default.
• W2884243985 modified "2023-10-18" @default.
• W2884243985 title "Lipids are the preferred substrate of the protist Naegleria gruberi, relative of a human brain pathogen" @default.
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• W2884243985 doi "https://doi.org/10.1101/370890" @default.
• W2884243985 hasPublicationYear "2018" @default.
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