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- W2884289363 abstract "IgE is an ancient and conserved immunoglobulin isotype with potent immunological function. Nevertheless, the regulation of IgE responses remains an enigma, and evidence of a role for IgE in host defense is limited. Here we report that topical exposure to a common environmental DNA-damaging xenobiotic initiated stress surveillance by γδTCR+ intraepithelial lymphocytes that resulted in class switching to IgE in B cells and the accumulation of autoreactive IgE. High-throughput antibody sequencing revealed that γδ T cells shaped the IgE repertoire by supporting specific variable-diversity-joining (VDJ) rearrangements with unique characteristics of the complementarity-determining region CDRH3. This endogenous IgE response, via the IgE receptor FcεRI, provided protection against epithelial carcinogenesis, and expression of the gene encoding FcεRI in human squamous-cell carcinoma correlated with good disease prognosis. These data indicate a joint role for immunosurveillance by T cells and by B cells in epithelial tissues and suggest that IgE is part of the host defense against epithelial damage and tumor development. Evidence of protective and homeostatic roles for IgE is relatively limited. Strid and colleagues demonstrate that γδ T cells induce switching to IgE that provides protection against experimentally induced epithelial cancer." @default.
- W2884289363 created "2018-08-03" @default.
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- W2884289363 date "2018-07-16" @default.
- W2884289363 modified "2023-10-10" @default.
- W2884289363 title "Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response" @default.
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- W2884289363 cites W1982680586 @default.
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- W2884289363 cites W1991945100 @default.
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- W2884289363 cites W1996448769 @default.
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- W2884289363 doi "https://doi.org/10.1038/s41590-018-0161-8" @default.
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