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- W2884293815 abstract "There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly available RNA sequencing data from Genotype-Tissue Expression (GTEx) project. GTEx provided RNA sequencing data of suprapubic (n=228) and lower leg (n=349) skins, which are photo-protected and photo-damaged. Using differentially expressed gene analysis and weighted gene co-expression network analysis, we characterized transcriptomic changes due to UV exposure and aging. Genes involved in skin development such as epidermal differentiation complex component (SPRR and LCE families), vasculature development (TGFBR1, TGFBR2, TGFBR3, KDR, FGF2, and VEGFC), and matrix metalloproteinase (MMP2, MMP3, MMP8, MMP10, and MMP13) were up-regulated by UV exposure. Also, down-regulated lipid metabolism and mitochondrial biogenesis were observed in photo-damaged skin. Moreover, wound healing process was universally down-regulated in suprapubic and lower leg with aging and further down-regulation of lipid metabolism and up-regulation of vasculature development were found as photo-aging signatures. In this study, dynamic transcriptomic alterations were observed in aged skin. Hence, our findings may help to discover a potential therapeutic target for skin rejuvenation." @default.
- W2884293815 created "2018-08-03" @default.
- W2884293815 creator A5027009676 @default.
- W2884293815 creator A5033460268 @default.
- W2884293815 creator A5084246147 @default.
- W2884293815 date "2018-07-18" @default.
- W2884293815 modified "2023-09-27" @default.
- W2884293815 title "Signatures of photo-aging and intrinsic aging in skin were revealed by transcriptome network analysis" @default.
- W2884293815 cites W151723881 @default.
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- W2884293815 cites W1631191622 @default.
- W2884293815 cites W1817454614 @default.
- W2884293815 cites W1869362176 @default.
- W2884293815 cites W1966327575 @default.
- W2884293815 cites W1976340458 @default.
- W2884293815 cites W1976842664 @default.
- W2884293815 cites W1977238629 @default.
- W2884293815 cites W1978340010 @default.
- W2884293815 cites W1984934719 @default.
- W2884293815 cites W1986348806 @default.
- W2884293815 cites W1987408673 @default.
- W2884293815 cites W1988565612 @default.
- W2884293815 cites W1991272056 @default.
- W2884293815 cites W2000293457 @default.
- W2884293815 cites W2002531179 @default.
- W2884293815 cites W2003720298 @default.
- W2884293815 cites W2013383709 @default.
- W2884293815 cites W2016857799 @default.
- W2884293815 cites W2018838463 @default.
- W2884293815 cites W2019002861 @default.
- W2884293815 cites W2022269012 @default.
- W2884293815 cites W2024423341 @default.
- W2884293815 cites W2027860649 @default.
- W2884293815 cites W2030721190 @default.
- W2884293815 cites W2035618305 @default.
- W2884293815 cites W2039773944 @default.
- W2884293815 cites W2045985596 @default.
- W2884293815 cites W2048878341 @default.
- W2884293815 cites W2052813747 @default.
- W2884293815 cites W2053127973 @default.
- W2884293815 cites W2055015048 @default.
- W2884293815 cites W2075346153 @default.
- W2884293815 cites W2076008843 @default.
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- W2884293815 cites W2107230853 @default.
- W2884293815 cites W2107398612 @default.
- W2884293815 cites W2114951137 @default.
- W2884293815 cites W2115914792 @default.
- W2884293815 cites W2120030068 @default.
- W2884293815 cites W2122463135 @default.
- W2884293815 cites W2126963475 @default.
- W2884293815 cites W2128218039 @default.
- W2884293815 cites W2129898665 @default.
- W2884293815 cites W2130410032 @default.
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- W2884293815 cites W2149541458 @default.
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- W2884293815 cites W2161162374 @default.
- W2884293815 cites W2164802216 @default.
- W2884293815 cites W2173318806 @default.
- W2884293815 cites W2179438025 @default.
- W2884293815 cites W2280727461 @default.
- W2884293815 cites W2311845087 @default.
- W2884293815 cites W2313350589 @default.
- W2884293815 cites W2315512556 @default.
- W2884293815 cites W2476542314 @default.
- W2884293815 cites W2507799362 @default.
- W2884293815 cites W2573540928 @default.
- W2884293815 cites W2610416242 @default.
- W2884293815 cites W2724698969 @default.
- W2884293815 cites W2733009937 @default.
- W2884293815 cites W2740005447 @default.
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- W2884293815 cites W2775144572 @default.
- W2884293815 cites W2781639398 @default.
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- W2884293815 doi "https://doi.org/10.18632/aging.101496" @default.
- W2884293815 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6075446" @default.
- W2884293815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30021930" @default.
- W2884293815 hasPublicationYear "2018" @default.
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